FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity

ID (Ontology)

GO:0003854 (Gene Ontology)

Definition

Catalysis of the reaction: a 3-beta-hydroxy-Delta(5)-steroid + NAD+ = a 3-oxo-Delta(5)-steroid + NADH + H+. Also acts on on 3-beta-hydroxypregn-5-en-20-one to form progesterone.[ EC:1 ]

Also Known As

"3-beta-hydroxy-D5-steroid dehydrogenase activity"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity (all annotations which use CV term, excluding "NOT" statements)
enables \| 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity

Spanning Tree (Parents/Children)

steroid dehydrogenase activity_________________________________________________________
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor__|
                                                                                       steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
                                                                                        |__3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity  1 rec.
                                                                                            |__cholesterol dehydrogenase (NAD+) activity

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Part of
Synonyms & Secondary IDs
Synonyms
	"3-beta-hydroxy-5-ene steroid dehydrogenase activity" RELATED[ EC:1 ] "3-beta-hydroxy-D5-steroid dehydrogenase activity" EXACT "3beta-HSDH" RELATED[ EC:1 ] "3beta-hydroxy steroid dehydrogenase/isomerase activity" RELATED[ EC:1 ] "3beta-hydroxy-5-ene steroid dehydrogenase activity" RELATED[ EC:1 ] "3beta-hydroxy-5-ene-steroid dehydrogenase activity" RELATED[ EC:1 ] "3beta-hydroxy-5-ene-steroid oxidoreductase activity" RELATED[ EC:1 ] "3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase activity" RELATED[ EC:1 ] "3beta-hydroxy-delta5-C27-steroid oxidoreductase" BROAD[ EC:1 ] "3beta-hydroxy-delta5-steroid dehydrogenase activity" RELATED[ EC:1 ] "3beta-hydroxy-delta5-steroid:NAD+ 3-oxidoreductase activity" RELATED[ EC:1 ] "5-ene-3-beta-hydroxysteroid dehydrogenase activity" RELATED[ EC:1 ] "delta5-3beta-hydroxysteroid dehydrogenase activity" RELATED[ EC:1 ] "progesterone reductase activity" BROAD[ EC:1 ] "steroid-delta5-3beta-ol dehydrogenase activity" RELATED[ EC:1 ]
Secondary IDs

External Crossreferences & Linkouts
	EC:1.1.1.145 MetaCyc:1.1.1.145-RXN Reactome:R-HSA-192097 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one" Reactome:R-HSA-193789 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one" Reactome:R-HSA-193816 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one" Reactome:R-HSA-196350 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione" Reactome:R-HSA-196372 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol" RHEA:24076 RHEA:43932 RHEA:56932