FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity ID (Ontology) GO:0003854 (Gene Ontology)
Definition Catalysis of the reaction: a 3-beta-hydroxy-Delta(5)-steroid + NAD+ = a 3-oxo-Delta(5)-steroid + NADH + H+. Also acts on on 3-beta-hydroxypregn-5-en-20-one to form progesterone.[ EC:1 ]
Also Known As "3-beta-hydroxy-D5-steroid dehydrogenase activity"
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
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 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity (all annotations which use CV term, excluding "NOT" statements)       1
     enables | 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity       1
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steroid dehydrogenase activity_________________________________________________________
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor__|
                                                                                       steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
                                                                                        |__3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity  1 rec.
                                                                                            |__cholesterol dehydrogenase (NAD+) activity
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Is a steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
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Synonyms
  • "3-beta-hydroxy-5-ene steroid dehydrogenase activity" RELATED[ EC:1 ]
    "3-beta-hydroxy-D5-steroid dehydrogenase activity" EXACT
    "3beta-HSDH" RELATED[ EC:1 ]
    "3beta-hydroxy steroid dehydrogenase/isomerase activity" RELATED[ EC:1 ]
    "3beta-hydroxy-5-ene steroid dehydrogenase activity" RELATED[ EC:1 ]
    "3beta-hydroxy-5-ene-steroid dehydrogenase activity" RELATED[ EC:1 ]
    "3beta-hydroxy-5-ene-steroid oxidoreductase activity" RELATED[ EC:1 ]
    "3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase activity" RELATED[ EC:1 ]
    "3beta-hydroxy-delta5-C27-steroid oxidoreductase" BROAD[ EC:1 ]
    "3beta-hydroxy-delta5-steroid dehydrogenase activity" RELATED[ EC:1 ]
    "3beta-hydroxy-delta5-steroid:NAD+ 3-oxidoreductase activity" RELATED[ EC:1 ]
    "5-ene-3-beta-hydroxysteroid dehydrogenase activity" RELATED[ EC:1 ]
    "delta5-3beta-hydroxysteroid dehydrogenase activity" RELATED[ EC:1 ]
    "progesterone reductase activity" BROAD[ EC:1 ]
    "steroid-delta5-3beta-ol dehydrogenase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.1.1.145
MetaCyc:1.1.1.145-RXN
Reactome:R-HSA-192097 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one"
Reactome:R-HSA-193789 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one"
Reactome:R-HSA-193816 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one"
Reactome:R-HSA-196350 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione"
Reactome:R-HSA-196372 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol"
RHEA:24076
RHEA:43932