FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity ID (Ontology) GO:0003857 (Gene Ontology)
Definition Catalysis of the reaction: a (3S)-3-hydroxyacyl-CoA + NAD+ = a 3-oxoacyl-CoA + NADH + H+.
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity (all annotations which use CV term, excluding "NOT" statements)
     enables | (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity       --
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  oxidoreductase activity, acting on CH-OH group of donors
   |__oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
       |__(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity  3 rec.
           |__long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity 1 rec.
           |__very long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase activity
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Is a oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
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Synonyms
  • "3-oxoacyl-thioester reductase activity" RELATED[ PubMed:19685079 ]
    "beta-hydroxyacyl dehydrogenase activity" RELATED[ EC:1 ]
    "beta-hydroxyacyl-coenzyme A synthetase activity" RELATED[ EC:1 ]
    "beta-hydroxyacylcoenzyme A dehydrogenase activity" RELATED[ EC:1 ]
    "beta-hydroxybutyrylcoenzyme A dehydrogenase activity" NARROW[ EC:1 ]
    "beta-keto-reductase activity" RELATED[ EC:1 ]
    "beta-ketoacyl-CoA reductase" BROAD[ EC:1 ]
    "L-3-hydroxyacyl CoA dehydrogenase activity" RELATED[ EC:1 ]
    "L-3-hydroxyacyl coenzyme A dehydrogenase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.1.1.35
MetaCyc:OHACYL-COA-DEHYDROG-RXN
Reactome:R-HSA-193455 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA"
Reactome:R-HSA-193508 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA"
Reactome:R-HSA-389995 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+"
Reactome:R-HSA-390251 "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA"
Reactome:R-HSA-508369 "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+"
Reactome:R-HSA-6809264 "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA"
Reactome:R-HSA-70837 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+"
Reactome:R-HSA-77254 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H"
Reactome:R-HSA-77283 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H"
Reactome:R-HSA-77303 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H"
Reactome:R-HSA-77312 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H"
Reactome:R-HSA-77323 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H"
Reactome:R-HSA-77331 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H"
Reactome:R-HSA-77342 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H"
RHEA:22432
RHEA:30799
RHEA:31143
RHEA:31179
RHEA:31187
RHEA:31195
RHEA:34851
RHEA:40211
RHEA:78919
RHEA:78923
RHEA:83003
RHEA:84419
RHEA:84683
RHEA:84687
UM-BBD_reactionID:r1063