FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

branched-chain 2-oxo acid dehydrogenase activity

ID (Ontology)

GO:0003863 (Gene Ontology)

Definition

Catalysis of the reaction: N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + 3-methyl-2-oxobutanoate + H+ = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] + CO2. Also acts on 4-methyl-2-oxopentanoate and (S)-3-methyl-2-oxopentanoate, so that it acts on the 2-oxo acids that derive from the action of transaminases on valine, leucine and isoleucine.

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Gene Groups	Genes
branched-chain 2-oxo acid dehydrogenase activity (all annotations which use CV term, excluding "NOT" statements)
contributes_to \| branched-chain 2-oxo acid dehydrogenase activity	--

Spanning Tree (Parents/Children)

  oxidoreductase activity, acting on the aldehyde or oxo group of donors
   |__oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
       |__branched-chain 2-oxo acid dehydrogenase activity  4 rec.

Spanning Tree View Settings
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Relationships
Is a	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Part of
Synonyms & Secondary IDs
Synonyms
	"2-oxoisocaproate dehydrogenase activity" RELATED[ EC:1 ] "2-oxoisovalerate (lipoate) dehydrogenase activity" RELATED[ EC:1 ] "3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity" NARROW "3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity" RELATED[ EC:1 ] "3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)" RELATED[ EC:1 ] "3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity" RELATED[ EC:1 ] "alpha-keto-alpha-methylvalerate dehydrogenase activity" RELATED[ EC:1 ] "alpha-ketoacid dehydrogenase activity" NARROW "alpha-ketoisocaproate dehydrogenase activity" RELATED[ EC:1 ] "alpha-ketoisocaproic dehydrogenase activity" RELATED[ EC:1 ] "alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity" RELATED[ EC:1 ] "alpha-ketoisovalerate dehydrogenase activity" RELATED[ EC:1 ] "alpha-oxoisocaproate dehydrogenase activity" RELATED[ EC:1 ] "BCKDH activity" RELATED[ EC:1 ] "BCOAD activity" RELATED[ EC:1 ] "branched chain keto acid dehydrogenase activity" RELATED[ EC:1 ] "branched-chain (-2-oxoacid) dehydrogenase (BCD) activity" RELATED[ EC:1 ] "branched-chain 2-keto acid dehydrogenase activity" RELATED[ EC:1 ] "branched-chain alpha-keto acid dehydrogenase activity" RELATED[ EC:1 ] "branched-chain alpha-oxo acid dehydrogenase activity" RELATED[ EC:1 ] "branched-chain keto acid dehydrogenase activity" RELATED[ EC:1 ] "branched-chain ketoacid dehydrogenase activity" RELATED[ EC:1 ] "dehydrogenase, 2-oxoisovalerate (lipoate) activity" RELATED[ EC:1 ] "dehydrogenase, branched chain alpha-keto acid activity" RELATED[ EC:1 ]
Secondary IDs

External Crossreferences & Linkouts
	EC:1.2.4.4 MetaCyc:1.2.4.4-RXN RHEA:13457 RHEA:84639 RHEA:84643