FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term 5-aminolevulinate synthase activity ID (Ontology) GO:0003870 (Gene Ontology)
Definition Catalysis of the reaction: glycine + H+ + succinyl-CoA = 5-aminolevulinate + CO2 + CoA.[ EC:2 ]
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 5-aminolevulinate synthase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | 5-aminolevulinate synthase activity
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  succinyltransferase activity
   |__N-succinyltransferase activity
       |__5-aminolevulinate synthase activity  1 rec.
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Is a N-succinyltransferase activity
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Synonyms
  • "5-aminolevulinate synthetase activity" RELATED[ EC:2 ]
    "5-aminolevulinic acid synthase activity" RELATED[ EC:2 ]
    "5-aminolevulinic acid synthetase activity" RELATED[ EC:2 ]
    "ALA synthase activity" RELATED[ EC:2 ]
    "ALA synthetase activity" RELATED[ EC:2 ]
    "ALAS activity" RELATED[ EC:2 ]
    "alpha-aminolevulinic acid synthase activity" RELATED[ EC:2 ]
    "aminolevulinate synthase activity" RELATED[ EC:2 ]
    "aminolevulinate synthetase activity" RELATED[ EC:2 ]
    "aminolevulinic acid synthase activity" RELATED[ EC:2 ]
    "aminolevulinic acid synthetase activity" RELATED[ EC:2 ]
    "aminolevulinic synthetase activity" RELATED[ EC:2 ]
    "delta-ALA synthetase activity" RELATED[ EC:2 ]
    "delta-aminolevulinate synthase activity" RELATED[ EC:2 ]
    "delta-aminolevulinate synthetase activity" RELATED[ EC:2 ]
    "delta-aminolevulinic acid synthase activity" RELATED[ EC:2 ]
    "delta-aminolevulinic acid synthetase activity" RELATED[ EC:2 ]
    "delta-aminolevulinic synthetase activity" RELATED[ EC:2 ]
    "succinyl-CoA:glycine C-succinyltransferase (decarboxylating)" RELATED[ EC:2 ]
Secondary IDs
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EC:2.3.1.37
KEGG_REACTION:R00830
MetaCyc:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN
Reactome:R-HSA-189442 "ALAS condenses SUCC-CoA and Gly to form dALA"
RHEA:12921