FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term 6-pyruvoyltetrahydropterin synthase activity ID (Ontology) GO:0003874 (Gene Ontology)
Definition Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H+ + triphosphate.[ EC:4 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 6-pyruvoyltetrahydropterin synthase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | 6-pyruvoyltetrahydropterin synthase activity
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  carbon-oxygen lyase activity
   |__carbon-oxygen lyase activity, acting on phosphates
       |__6-pyruvoyltetrahydropterin synthase activity  1 rec.
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Is a carbon-oxygen lyase activity, acting on phosphates
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Synonyms
  • "2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase activity" RELATED
    "2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)" RELATED
    "6-pyruvoyl tetrahydrobiopterin synthase activity" RELATED[ EC:4 ]
    "PTPS activity" RELATED[ EC:4 ]
Secondary IDs
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EC:4.2.3.12
KEGG_REACTION:R04286
MetaCyc:4.2.3.12-RXN
Reactome:R-HSA-1474184 "DHNTP is dephosphorylated by PTPS to PTHP"
RHEA:22048