FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term ATP citrate synthase activity ID (Ontology) GO:0003878 (Gene Ontology)
Definition Catalysis of the reaction: acetyl-CoA + ADP + H+ + oxaloacetate + phosphate = ATP + citrate + CoA.
Also Known As"ATP-citrate (pro-S)-lyase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 ATP citrate synthase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | ATP citrate synthase activity
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  acyltransferase activity
   |__acyltransferase activity, acyl groups converted into alkyl on transfer
       |__ATP citrate synthase activity  1 rec.
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Is a acyltransferase activity, acyl groups converted into alkyl on transfer
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Synonyms
  • "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity" RELATED[ EC:2 ]
    "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)" RELATED[ EC:2 ]
    "acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]" RELATED[ EC:2 ]
    "adenosine triphosphate citrate lyase activity" RELATED[ EC:2 ]
    "ATP citrate (pro-S)-lyase activity" RELATED[ EC:2 ]
    "ATP-citrate (pro-S)-lyase activity" EXACT
    "ATP-citrate (pro-S-)-lyase activity" RELATED[ EC:2 ]
    "ATP-citric lyase activity" RELATED[ EC:2 ]
    "ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity" RELATED[ EC:2 ]
    "ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)" RELATED
    "citrate cleavage enzyme activity" RELATED[ EC:2 ]
    "citrate-ATP lyase activity" RELATED[ EC:2 ]
    "citric cleavage enzyme activity" RELATED[ EC:2 ]
Secondary IDs
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EC:2.3.3.8
KEGG_REACTION:R00352
MetaCyc:ATP-CITRATE-PRO-S--LYASE-RXN
Reactome:R-HSA-75848 "ACLY tetramer transforms CIT to Ac-CoA"
RHEA:21160