FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term DNA (cytosine-5-)-methyltransferase activity ID (Ontology) GO:0003886 (Gene Ontology)
Definition Catalysis of the reaction: a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H+ + S-adenosyl-L-homocysteine.
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Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 DNA (cytosine-5-)-methyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | DNA (cytosine-5-)-methyltransferase activity
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methyltransferase activity
 |__S-adenosylmethionine-dependent methyltransferase activity__
 |__DNA-methyltransferase activity_____________________________|
catalytic activity, acting on DNA                              |
 |__DNA-methyltransferase activity_____________________________|
                                                               DNA (cytosine-5-)-methyltransferase activity  1 rec.
                                                                |__ATP-dependent DNA (cytosine-5-)-methyltransferase activity
                                                                |__DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
                                                                |__DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates
                                                                |__DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates
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Is a S-adenosylmethionine-dependent methyltransferase activity
DNA-methyltransferase activity
Part of
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Synonyms
  • "cytosine 5-methyltransferase activity" RELATED[ EC:2 ]
    "cytosine DNA methylase activity" BROAD[ EC:2 ]
    "cytosine DNA methyltransferase activity" BROAD[ EC:2 ]
    "cytosine-specific DNA methyltransferase activity" RELATED[ EC:2 ]
    "deoxyribonucleic (cytosine-5-)-methyltransferase activity" RELATED[ EC:2 ]
    "deoxyribonucleic acid (cytosine-5-)-methyltransferase activity" RELATED[ EC:2 ]
    "deoxyribonucleic methylase activity" BROAD[ EC:2 ]
    "DNA 5-cytosine methylase activity" RELATED[ EC:2 ]
    "DNA cytosine C(5) methylase activity" RELATED[ EC:2 ]
    "DNA cytosine C5 methylase activity" RELATED[ EC:2 ]
    "DNA cytosine methylase activity" BROAD[ EC:2 ]
    "DNA-cytosine 5-methylase activity" RELATED[ EC:2 ]
    "DNA-cytosine methyltransferase activity" BROAD[ EC:2 ]
    "methylphosphotriester-DNA methyltransferase activity" RELATED[ EC:2 ]
    "modification methylase activity" RELATED[ EC:2 ]
    "restriction-modification system activity" RELATED[ EC:2 ]
    "S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase activity" RELATED[ EC:2 ]
    "site-specific DNA-methyltransferase (cytosine-specific) activity" NARROW[ EC:2 ]
    "type II DNA methylase activity" RELATED[ EC:2 ]
Secondary IDs
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EC:2.1.1.37
MetaCyc:DNA-CYTOSINE-5--METHYLTRANSFERASE-RXN
RHEA:13681