FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term DNA-directed DNA polymerase activity ID (Ontology) GO:0003887 (Gene Ontology)
Definition Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time.[ EC:2 ]
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       9
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 Gene Groups Genes
 DNA-directed DNA polymerase activity (all annotations which use CV term, excluding "NOT" statements)      11      9
     enables | DNA-directed DNA polymerase activity       --       9
Spanning Tree (Parents/Children)
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nucleotidyltransferase activity____
catalytic activity, acting on DNA__|
                                   DNA polymerase activity
                                    |__DNA-directed DNA polymerase activity  20 rec.
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Is a DNA polymerase activity
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Synonyms
  • "alpha DNA polymerase activity" NARROW
    "beta DNA polymerase activity" NARROW
    "delta DNA polymerase activity" NARROW
    "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" RELATED[ EC:2 ]
    "deoxyribonucleic acid duplicase activity" RELATED[ EC:2 ]
    "deoxyribonucleic duplicase activity" RELATED[ EC:2 ]
    "deoxyribonucleic polymerase I" NARROW[ EC:2 ]
    "DNA duplicase activity" RELATED[ EC:2 ]
    "DNA nucleotidyltransferase (DNA-directed) activity" RELATED[ EC:2 ]
    "DNA polymerase alpha" NARROW[ EC:2 ]
    "DNA polymerase beta" NARROW[ EC:2 ]
    "DNA polymerase gamma" NARROW[ EC:2 ]
    "DNA polymerase I" NARROW[ EC:2 ]
    "DNA polymerase II" NARROW[ EC:2 ]
    "DNA polymerase III" NARROW[ EC:2 ]
    "DNA polymerase V activity" NARROW
    "DNA replicase activity" RELATED[ EC:2 ]
    "DNA-dependent DNA polymerase activity" RELATED[ EC:2 ]
    "duplicase" BROAD[ EC:2 ]
    "epsilon DNA polymerase activity" NARROW
    "eta DNA polymerase activity" NARROW
    "gamma DNA-directed DNA polymerase activity" NARROW
    "iota DNA polymerase activity" NARROW
    "kappa DNA polymerase activity" NARROW
    "Klenow fragment" NARROW[ EC:2 ]
    "lambda DNA polymerase activity" NARROW
    "mu DNA polymerase activity" NARROW
    "nu DNA polymerase activity" NARROW
    "sequenase" RELATED[ EC:2 ]
    "sigma DNA polymerase activity" NARROW
    "Taq DNA polymerase" NARROW[ EC:2 ]
    "Taq Pol I" NARROW[ EC:2 ]
    "Tca DNA polymerase" NARROW[ EC:2 ]
    "theta DNA polymerase activity" NARROW
    "zeta DNA polymerase activity" NARROW
Secondary IDs
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EC:2.7.7.7
MetaCyc:DNA-DIRECTED-DNA-POLYMERASE-RXN
Reactome:R-HSA-110311 "POLZ extends translesion synthesis"
Reactome:R-HSA-110317 "Insertion of correct bases opposite the lesion by POLH"
Reactome:R-HSA-110319 "Elongation by POLH"
Reactome:R-HSA-110368 "POLD,POLE-mediated DNA strand displacement synthesis"
Reactome:R-HSA-111253 "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site"
Reactome:R-HSA-164505 "Synthesis of full-length duplex viral DNA with a discontinuous plus strand"
Reactome:R-HSA-164513 "3' PPT-primed initiation of plus-strand DNA synthesis"
Reactome:R-HSA-174427 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere"
Reactome:R-HSA-174444 "Formation of C-strand Okazaki fragments"
Reactome:R-HSA-5358579 "DNA polymerase delta polymerizes DNA across single stranded gap"
Reactome:R-HSA-5649723 "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution"
Reactome:R-HSA-5649883 "POLB-mediated DNA strand displacement synthesis"
Reactome:R-HSA-5653840 "POLD,POLE complete replication of damaged DNA after TLS"
Reactome:R-HSA-5655892 "POLK incorporates dNMP opposite to damaged DNA base"
Reactome:R-HSA-5655965 "POLK and POLZ cooperate in elongation of mispaired primer termini"
Reactome:R-HSA-5656148 "POLI incorporates dNMP opposite to damaged DNA base"
Reactome:R-HSA-5656158 "POLZ elongates POLI-incorporated dNMP"
Reactome:R-HSA-5687360 "POLL or POLM extends aligned DNA DSB ends to fill gaps"
Reactome:R-HSA-5687640 "POLQ extends annealed 3'-ssDNA overhangs in MMEJ"
Reactome:R-HSA-5691001 "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER"
Reactome:R-HSA-5693593 "D-loop extension by DNA polymerases"
Reactome:R-HSA-6782208 "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER"
Reactome:R-HSA-6786166 "Translesion synthesis across unhooked ICL by POLN"
Reactome:R-HSA-68950 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin"
Reactome:R-HSA-69116 "Formation of Okazaki fragments"
Reactome:R-HSA-73932 "Resynthesis of excised residue by POLB"
Reactome:R-HSA-9710480 "Decitabine triphosphate incorporates into DNA"