FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term DNA-directed RNA polymerase activity ID (Ontology) GO:0003899 (Gene Ontology)
Definition Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.[ EC:2 ]
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      20
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 Gene Groups Genes
 DNA-directed RNA polymerase activity (all annotations which use CV term, excluding "NOT" statements)       7     20
     contributes_to | DNA-directed RNA polymerase activity       --      18
     enables | DNA-directed RNA polymerase activity       --      20
Spanning Tree (Parents/Children)
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  RNA polymerase activity
   |__5'-3' RNA polymerase activity
       |__DNA-directed RNA polymerase activity  27 rec.
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Is a 5'-3' RNA polymerase activity
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Synonyms
  • "C ribonucleic acid formation factors" RELATED[ EC:2 ]
    "C RNA formation factors" RELATED[ EC:2 ]
    "deoxyribonucleic acid-dependent ribonucleic acid polymerase activity" RELATED[ EC:2 ]
    "DNA-dependent ribonucleate nucleotidyltransferase activity" RELATED[ EC:2 ]
    "DNA-dependent RNA nucleotidyltransferase activity" RELATED[ EC:2 ]
    "DNA-dependent RNA polymerase activity" RELATED[ EC:2 ]
    "DNA-directed RNA polymerase I activity" NARROW
    "DNA-directed RNA polymerase II activity" NARROW
    "DNA-directed RNA polymerase III activity" NARROW
    "nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) activity" RELATED[ EC:2 ]
    "RNA nucleotidyltransferase (DNA-directed) activity" RELATED[ EC:2 ]
    "RNA polymerase I activity" NARROW[ EC:2 ]
    "RNA polymerase II activity" NARROW[ EC:2 ]
    "RNA polymerase III activity" NARROW[ EC:2 ]
    "RNA polymerase IV activity" NARROW
    "RNA polymerase V activity" NARROW
    "transcriptase" BROAD[ EC:2 ]
Secondary IDs
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EC:2.7.7.6
MetaCyc:DNA-DIRECTED-RNA-POLYMERASE-RXN
Reactome:R-HSA-111264 "Addition of nucleotides between position +11 and +30"
Reactome:R-HSA-167113 "Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition"
Reactome:R-HSA-167115 "Addition of nucleotides between position +11 and +30 on HIV-1 transcript"
Reactome:R-HSA-167117 "Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition"
Reactome:R-HSA-167121 "Addition of the third nucleotide on the nascent HIV-1 transcript"
Reactome:R-HSA-167136 "Addition of nucleotides 5 through 9 on the growing HIV-1 transcript"
Reactome:R-HSA-174425 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere"
Reactome:R-HSA-203901 "Pol II mediated transcription of microRNA genes"
Reactome:R-HSA-427366 "Transcription of intergenic spacer of the rRNA gene"
Reactome:R-HSA-5601926 "RNA polymerase II polymerizes primary piRNA transcript"
Reactome:R-HSA-6781824 "Active RNA Pol II complex transcribes lesion-containing DNA template"
Reactome:R-HSA-68913 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin"
Reactome:R-HSA-74986 "Elongation of pre-rRNA transcript"
Reactome:R-HSA-75850 "Addition of the third nucleotide on the nascent transcript"
Reactome:R-HSA-75869 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition"
Reactome:R-HSA-75873 "Addition of Nucleotides 5 through 9 on the growing Transcript"
Reactome:R-HSA-76576 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition"
Reactome:R-HSA-9670149 "TERRA transcription"
Reactome:R-HSA-9697084 "Defective RpoB in Mtb RNAP transcribes RNA polyanion"
Reactome:R-HSA-9697085 "RNAP transcribes Mtb RNA polyanion"