FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term DNA-(apurinic or apyrimidinic site) endonuclease activity ID (Ontology) GO:0003906 (Gene Ontology)
Definition Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER).
Also Known As"abasic deoxyendoribonuclease activity" ; "AP deoxyendoribonuclease activity" ; "apurinic deoxyendoribonuclease activity" (for all, see Synonyms field below)
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Genes
 DNA-(apurinic or apyrimidinic site) endonuclease activity (all annotations which use CV term, excluding "NOT" statements)
     enables | DNA-(apurinic or apyrimidinic site) endonuclease activity
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endonuclease activity__
DNA nuclease activity__|
                       DNA endonuclease activity
                        |__DNA-(apurinic or apyrimidinic site) endonuclease activity  10 rec.
                            |__class I DNA-(apurinic or apyrimidinic site) endonuclease activity 6 rec.
                            |__class II DNA-(apurinic or apyrimidinic site) endonuclease activity 4 rec.
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Is a DNA endonuclease activity
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Synonyms
  • "abasic deoxyendoribonuclease activity" EXACT
    "AP deoxyendoribonuclease activity" EXACT
    "apurinic deoxyendoribonuclease activity" EXACT
    "apurinic/apyrimidinic endodeoxyribonuclease activity" EXACT
    "apyrimidinic deoxyendoribonuclease activity" EXACT
    "deoxyribonuclease (apurinic or apyrimidinic) activity" EXACT
    "endonuclease VIII activity" RELATED
    "UV endonuclease" BROAD
Secondary IDs
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Reactome:R-HSA-110375 "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break"
Reactome:R-HSA-5649711 "NEIL1,NEIL2 incises DNA strand 5' to the AP site"
Reactome:R-HSA-5649725 "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP)"