FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term methylated-DNA-[protein]-cysteine S-methyltransferase activity ID (Ontology) GO:0003908 (Gene Ontology)
Definition Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine.[ EC:2 ]
Also Known As"DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase activity" ; "MGMT"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 methylated-DNA-[protein]-cysteine S-methyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | methylated-DNA-[protein]-cysteine S-methyltransferase activity
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methyltransferase activity
 |__S-methyltransferase activity_________
 |__protein methyltransferase activity___|
catalytic activity, acting on a protein  |
 |__protein methyltransferase activity___|
                                         methylated-DNA-[protein]-cysteine S-methyltransferase activity  1 rec.
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Is a S-methyltransferase activity
protein methyltransferase activity
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Synonyms
  • "6-O-methylguanine-DNA methyltransferase activity" RELATED[ EC:2 ]
    "DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase activity" EXACT
    "DNA-6-O-methylguanine:protein-L-cysteine S-methyltransferase activity" RELATED[ EC:2 ]
    "methylated-DNA-protein-cysteine S-methyltransferase activity" RELATED[ EC:2 ]
    "MGMT" EXACT
    "O-6-methylguanine-DNA-alkyltransferase activity" RELATED[ EC:2 ]
    "O6-alkylguanine-DNA alkyltransferase" BROAD
Secondary IDs
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EC:2.1.1.63
MetaCyc:2.1.1.63-RXN
Reactome:R-HSA-73892 "MGMT/hAGT mediated DNA Damage Reversal"
RHEA:24000