FB2026_03 , released September 17, 2026
CV Term Report
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Term DNA ligase activity ID (Ontology) GO:0003909 (Gene Ontology)
Definition Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+.[ ISBN:0716720094 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 DNA ligase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | DNA ligase activity
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ligase activity
 |__ligase activity, forming phosphoric ester bonds__
catalytic activity, acting on a nucleic acid         |
 |__catalytic activity, acting on DNA________________|
                                                     DNA ligase activity  4 rec.
                                                      |__DNA ligase (ATP) activity 4 rec.
                                                      |__DNA ligase (NAD+) activity
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Is a ligase activity, forming phosphoric ester bonds
catalytic activity, acting on DNA
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Reactome:R-HSA-174456 "Joining of adjacent Okazaki fragments of the C-strand"
Reactome:R-HSA-175258 "2-LTR formation due to circularization of viral DNA"
Reactome:R-HSA-5358592 "DNA ligase I ligates single stranded nick in double stranded DNA"
Reactome:R-HSA-5649734 "LIG3 ligates NEIL1,NEIL2-generated single strand break"
Reactome:R-HSA-5651789 "LIG1 bound to POLB ligates SSB"
Reactome:R-HSA-5651805 "LIG1 bound to APEX1 and PCNA ligates SSB"
Reactome:R-HSA-5687675 "LIG3 ligates remaining SSBs in MMEJ"
Reactome:R-HSA-5690997 "Ligation of newly synthesized repair patch to incised DNA in GG-NER"
Reactome:R-HSA-5693604 "XRCC4:LIG4 ligates DNA DSB ends during NHEJ"
Reactome:R-HSA-6782227 "Ligation of newly synthesized repair patch to incised DNA in TC-NER"
Reactome:R-HSA-69173 "Joining of adjacent Okazaki fragments"
Reactome:R-HSA-73931 "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway"