FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

DNA topoisomerase activity

ID (Ontology)

GO:0003916 (Gene Ontology)

Definition

Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.[ PubMed:8811192 ]

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Gene Groups	Genes
DNA topoisomerase activity (all annotations which use CV term, excluding "NOT" statements)
enables \| DNA topoisomerase activity	--

Spanning Tree (Parents/Children)

macromolecular conformation isomerase activity
 |__nucleic acid conformation isomerase activity__
catalytic activity, acting on a nucleic acid      |
 |__catalytic activity, acting on DNA_____________|
                                                  DNA topoisomerase activity  9 rec.
                                                   |__DNA topoisomerase type I (single strand cut, ATP-independent) activity 5 rec.
                                                   |__DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity 3 rec.
                                                   |   |__DNA negative supercoiling activity
                                                   |__reverse gyrase activity

Spanning Tree View Settings
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Relationships
Is a	nucleic acid conformation isomerase activity catalytic activity, acting on DNA
Part of
Synonyms & Secondary IDs
Synonyms

Secondary IDs

External Crossreferences & Linkouts