FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
Help Close All Open All
General Information
Term DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity ID (Ontology) GO:0003918 (Gene Ontology)
Definition Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.[ PubMed:8811192 ]
Also Known As "DNA topoisomerase type II activity"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       2
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity (all annotations which use CV term, excluding "NOT" statements)       1      2
     enables | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity       --       2
Spanning Tree (Parents/Children)
Only view relationship: 
nucleic acid conformation isomerase activity
 |__DNA topoisomerase activity_____________
catalytic activity, acting on DNA          |
 |__DNA topoisomerase activity_____________|
 |__ATP-dependent activity, acting on DNA__|
ATP-dependent activity                     |
 |__ATP-dependent activity, acting on DNA__|
                                           DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity  3 rec.
                                            |__DNA negative supercoiling activity
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a DNA topoisomerase activity
ATP-dependent activity, acting on DNA
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "deoxyribonucleate topoisomerase" BROAD
    "deoxyribonucleic topoisomerase activity" BROAD[ EC:5 ]
    "DNA topoisomerase (ATP-hydrolysing)" RELATED[ EC:5 ]
    "DNA topoisomerase II" NARROW[ EC:5 ]
    "DNA topoisomerase II activity" NARROW
    "DNA topoisomerase IV activity" NARROW
    "DNA topoisomerase type II activity" EXACT
    "topoisomerase" BROAD[ EC:5 ]
    "topoisomerase II" NARROW
    "type II DNA topoisomerase activity" RELATED[ EC:5 ]
Secondary IDs
hide External Crossreferences & Linkouts
EC:5.6.2.2
MetaCyc:5.99.1.3-RXN
Wikipedia:Type_II_topoisomerase