FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term GMP synthase (glutamine-hydrolyzing) activity ID (Ontology) GO:0003922 (Gene Ontology)
Definition Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H+.
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 GMP synthase (glutamine-hydrolyzing) activity (all annotations which use CV term, excluding "NOT" statements)
     enables | GMP synthase (glutamine-hydrolyzing) activity
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  ligase activity, forming carbon-nitrogen bonds
   |__carbon-nitrogen ligase activity, with glutamine as amido-N-donor
       |__GMP synthase (glutamine-hydrolyzing) activity  1 rec.
           |__GMP synthase activity 1 rec.
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Is a carbon-nitrogen ligase activity, with glutamine as amido-N-donor
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Synonyms
  • "glutamine amidotransferase activity" RELATED[ EC:6 ]
    "GMP synthase (glutamine-hydrolysing)" RELATED[ EC:6 ]
    "GMP synthetase (glutamine-hydrolysing)" RELATED[ EC:6 ]
    "GMP synthetase (glutamine-hydrolyzing) activity" RELATED[ EC:6 ]
    "guanosine 5'-monophosphate synthetase activity" RELATED[ EC:6 ]
    "guanosine monophosphate synthetase (glutamine-hydrolyzing)" RELATED[ EC:6 ]
    "guanylate synthetase (glutamine-hydrolyzing)" RELATED[ EC:6 ]
    "xanthosine 5'-phosphate amidotransferase activity" RELATED[ EC:6 ]
    "xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)" RELATED[ EC:6 ]
Secondary IDs
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EC:6.3.5.2
MetaCyc:GMP-SYN-GLUT-RXN
Reactome:R-HSA-73792 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate"
Reactome:R-HSA-9748957 "GMPS dimer transforms 6TXMP to 6TGMP"
RHEA:11680
Wikipedia:GMP_synthase_(glutamine-hydrolysing)