FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term GPI-anchor transamidase activity ID (Ontology) GO:0003923 (Gene Ontology)
Definition Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor.[ ISBN:0471331309 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 GPI-anchor transamidase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | GPI-anchor transamidase activity       --
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endopeptidase activity
 |__cysteine-type endopeptidase activity___________________
cysteine-type peptidase activity                           |
 |__cysteine-type endopeptidase activity___________________|
transferase activity                                       |
 |__transferase activity, transferring nitrogenous groups__|
                                                           GPI-anchor transamidase activity  3 rec.
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Is a cysteine-type endopeptidase activity
transferase activity, transferring nitrogenous groups
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Reactome:R-HSA-162836 "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide"