FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term GTP cyclohydrolase I activity ID (Ontology) GO:0003934 (Gene Ontology)
Definition Catalysis of the reaction: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H+.[ EC:3 ]
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Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Genes
 GTP cyclohydrolase I activity (all annotations which use CV term, excluding "NOT" statements)
     enables | GTP cyclohydrolase I activity
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  cyclohydrolase activity
   |__GTP cyclohydrolase activity
       |__GTP cyclohydrolase I activity  1 rec.
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Is a GTP cyclohydrolase activity
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Synonyms
  • "dihydroneopterin triphosphate synthase activity" RELATED[ EC:3 ]
    "GTP 7,8-8,9-dihydrolase activity" RELATED[ EC:3 ]
    "GTP 8-formylhydrolase activity" RELATED[ EC:3 ]
    "guanosine triphosphate 8-deformylase activity" RELATED[ EC:3 ]
    "guanosine triphosphate cyclohydrolase activity" RELATED[ EC:3 ]
Secondary IDs
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EC:3.5.4.16
KEGG_REACTION:R00424
MetaCyc:GTP-CYCLOHYDRO-I-RXN
Reactome:R-HSA-1474146 "GCH1 reduces GTP to dihydroneopterin triphosphate"
RHEA:17473