FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term IMP dehydrogenase activity ID (Ontology) GO:0003938 (Gene Ontology)
Definition Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+.[ EC:1 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 IMP dehydrogenase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | IMP dehydrogenase activity
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  oxidoreductase activity, acting on CH-OH group of donors
   |__oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
       |__IMP dehydrogenase activity  1 rec.
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Is a oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
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Synonyms
  • "IMP oxidoreductase activity" RELATED[ EC:1 ]
    "IMP:NAD+ oxidoreductase activity" RELATED[ EC:1 ]
    "inosinate dehydrogenase activity" RELATED[ EC:1 ]
    "inosine 5'-monophosphate dehydrogenase activity" RELATED[ EC:1 ]
    "inosine monophosphate dehydrogenase activity" RELATED[ EC:1 ]
    "inosine monophosphate oxidoreductase activity" RELATED[ EC:1 ]
    "inosine-5'-phosphate dehydrogenase activity" RELATED[ EC:1 ]
    "inosinic acid dehydrogenase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.1.1.205
MetaCyc:IMP-DEHYDROG-RXN
Reactome:R-HSA-73794 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]"
Reactome:R-HSA-9748945 "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP"
RHEA:11708