FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term L-iditol 2-dehydrogenase (NAD+) activity ID (Ontology) GO:0003939 (Gene Ontology)
Definition Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+. Acts on a number of sugar alcohols, including (but not limited to) L-iditol, D-glucitol, D-xylitol, and D-galactitol.[ EC:1 PubMed:13373783 ]
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 L-iditol 2-dehydrogenase (NAD+) activity (all annotations which use CV term, excluding "NOT" statements)
     enables | L-iditol 2-dehydrogenase (NAD+) activity       --
 NOT | enables | L-iditol 2-dehydrogenase (NAD+) activity       --
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  alcohol dehydrogenase [NAD(P)+] activity
   |__alcohol dehydrogenase (NAD+) activity
       |__L-iditol 2-dehydrogenase (NAD+) activity  3 rec.
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Is a alcohol dehydrogenase (NAD+) activity
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Synonyms
  • "glucitol dehydrogenase activity" RELATED[ EC:1 ]
    "L-iditol (sorbitol) dehydrogenase activity" RELATED[ EC:1 ]
    "L-iditol:NAD oxidoreductase activity" RELATED[ EC:1 ]
    "L-iditol:NAD+ 5-oxidoreductase activity" RELATED[ EC:1 ]
    "NAD+-dependent sorbitol dehydrogenase activity" RELATED[ EC:1 ]
    "NAD-dependent sorbitol dehydrogenase activity" RELATED[ EC:1 ]
    "NAD-sorbitol dehydrogenase" RELATED[ EC:1 ]
    "polyol dehydrogenase activity" BROAD[ EC:1 ]
    "sorbitol dehydrogenase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.1.1.14
MetaCyc:L-IDITOL-2-DEHYDROGENASE-RXN
Reactome:R-HSA-5652195 "SORD oxidizes D-sorbitol to Fru"
RHEA:10160
RHEA:33031