FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term L-iduronidase activity ID (Ontology) GO:0003940 (Gene Ontology)
Definition Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate. Can also hydrolyze alpha-L-iduronosidic linkages in heparan sulfate.[ EC:3 PubMed:35011691 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 L-iduronidase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | L-iduronidase activity
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  hydrolase activity, acting on glycosyl bonds
   |__hydrolase activity, hydrolyzing O-glycosyl compounds
       |__L-iduronidase activity  1 rec.
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Is a hydrolase activity, hydrolyzing O-glycosyl compounds
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Synonyms
  • "alpha-L-iduronidase activity" RELATED[ EC:3 ]
    "glycosaminoglycan alpha-L-iduronohydrolase activity" RELATED[ EC:3 ]
Secondary IDs
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EC:3.2.1.76
MetaCyc:3.2.1.76-RXN
Reactome:R-HSA-1678716 "IDUA cleaves iduronate from HS chain"
Reactome:R-HSA-1793186 "IDUA hydrolyses the unsulfated alpha-L-iduronosidic link in DS"
Reactome:R-HSA-2090037 "IDUA hydrolyses Heparan sulfate chain(6)"
Reactome:R-HSA-2206299 "Defective IDUA does not hydrolyse Heparan sulfate chain(6)"
Reactome:R-HSA-9036037 "Defective IDUA does not hydrolyse Heparan sulfate chain(1)"
Reactome:R-HSA-9036041 "Defective IDUA does not hydrolyse the unsulfated alpha-L-iduronosidic link in DS"