FB2026_03 , released September 17, 2026
CV Term Report
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Term NAD+ synthase (glutamine-hydrolyzing) activity ID (Ontology) GO:0003952 (Gene Ontology)
Definition Catalysis of the reaction: deamido-NAD+ + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD+ + H+.
Also Known As"NAD synthase (glutamine-hydrolyzing) activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 NAD+ synthase (glutamine-hydrolyzing) activity (all annotations which use CV term, excluding "NOT" statements)
     enables | NAD+ synthase (glutamine-hydrolyzing) activity
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  ligase activity, forming carbon-nitrogen bonds
   |__carbon-nitrogen ligase activity, with glutamine as amido-N-donor
       |__NAD+ synthase (glutamine-hydrolyzing) activity  1 rec.
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Is a carbon-nitrogen ligase activity, with glutamine as amido-N-donor
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Synonyms
  • "deamido-NAD+:L-glutamine amido-ligase (AMP-forming)" RELATED[ EC:6 ]
    "desamidonicotinamide adenine dinucleotide amidotransferase activity" RELATED[ EC:6 ]
    "DPN synthetase activity" RELATED[ EC:6 ]
    "NAD synthase (glutamine-hydrolyzing) activity" EXACT
    "NAD synthetase (glutamine-hydrolysing)" RELATED[ EC:6 ]
    "NAD(+) synthetase (glutamine-hydrolyzing) activity" RELATED[ EC:6 ]
    "NAD+ synthase (glutamine-hydrolysing)" RELATED[ EC:6 ]
    "NAD+ synthetase (glutamine-hydrolyzing)" RELATED[ EC:6 ]
    "nicotinamide adenine dinucleotide synthetase (glutamine) activity" RELATED[ EC:6 ]
Secondary IDs
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EC:6.3.5.1
MetaCyc:NAD-SYNTH-GLN-RXN
Reactome:R-HSA-197271 "NADSYN1 hexamer amidates NAAD to NAD+"
RHEA:24384
Wikipedia:NAD+_synthase_(glutamine-hydrolysing)