FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term NADPH-hemoprotein reductase activity ID (Ontology) GO:0003958 (Gene Ontology)
Definition Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.[ EC:1 ]
Also Known As "NADPH-ferrihemoprotein reductase activity" ; "NADPH:cytochrome c reductase activity" ; "NADPH:cytochrome P450 reductase activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 NADPH-hemoprotein reductase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | NADPH-hemoprotein reductase activity
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  oxidoreductase activity, acting on NAD(P)H
   |__oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
       |__NADPH-hemoprotein reductase activity  1 rec.
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Is a oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
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Synonyms
  • "aldehyde reductase (NADPH-dependent) activity" RELATED[ EC:1 ]
    "CPR activity" RELATED[ EC:1 ]
    "cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent) activity" NARROW[ EC:1 ]
    "cytochrome P-450 reductase activity" RELATED[ EC:1 ]
    "cytochrome P450 reductase activity" NARROW[ EC:1 ]
    "dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW[ EC:1 ]
    "FAD-cytochrome c reductase activity" RELATED[ EC:1 ]
    "ferrihemoprotein P-450 reductase activity" RELATED[ EC:1 ]
    "NADP--cytochrome c reductase activity" NARROW[ EC:1 ]
    "NADP--cytochrome reductase activity" NARROW[ EC:1 ]
    "NADPH--cytochrome c oxidoreductase activity" NARROW[ EC:1 ]
    "NADPH--cytochrome c reductase activity" NARROW[ EC:1 ]
    "NADPH--cytochrome P450 oxidoreductase activity" NARROW[ EC:1 ]
    "NADPH--cytochrome P450 reductase activity" NARROW[ EC:1 ]
    "NADPH--ferricytochrome c oxidoreductase activity" NARROW[ EC:1 ]
    "NADPH--ferrihemoprotein reductase activity" NARROW[ EC:1 ]
    "NADPH-cytochrome P-450 oxidoreductase activity" RELATED[ EC:1 ]
    "NADPH-cytochrome p-450 reductase activity" RELATED[ EC:1 ]
    "NADPH-dependent cytochrome c reductase activity" NARROW[ EC:1 ]
    "NADPH-ferrihemoprotein reductase activity" EXACT
    "NADPH:cytochrome c reductase activity" EXACT
    "NADPH:cytochrome P450 reductase activity" EXACT
    "NADPH:ferrihemoprotein oxidoreductase activity" RELATED[ EC:1 ]
    "NADPH:hemoprotein oxidoreductase activity" RELATED[ EC:1 ]
    "NADPH:P-450 reductase activity" RELATED[ EC:1 ]
    "NADPH:P450 reductase activity" NARROW[ EC:1 ]
    "POR" RELATED[ EC:1 ]
    "reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW[ EC:1 ]
    "reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate) activity" NARROW[ EC:1 ]
    "TPNH(2) cytochrome c reductase activity" NARROW[ EC:1 ]
    "TPNH-cytochrome c reductase activity" NARROW[ EC:1 ]
    "TPNH2 cytochrome c reductase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.6.2.4
MetaCyc:NADPH--FERRIHEMOPROTEIN-REDUCTASE-RXN
Reactome:R-HSA-76494 "POR reduces CYP450:Fe3+ to CYP450:Fe2+"
RHEA:24040