FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term acetyl-CoA synthetase activity ID (Ontology) GO:0003987 (Gene Ontology)
Definition Catalysis of the reaction: acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate.
Also Known As"acetate-CoA ligase activity" ; "acetyl-coenzyme A synthetase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 acetyl-CoA synthetase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | acetyl-CoA synthetase activity       --
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  acid-thiol ligase activity
   |__CoA-ligase activity
       |__acetyl-CoA synthetase activity  3 rec.
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Is a CoA-ligase activity
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Synonyms
  • "acetate thiokinase activity" BROAD[ EC:6 ]
    "acetate to acetyl-CoA" RELATED
    "acetate-CoA ligase activity" EXACT
    "acetate:CoA ligase (AMP-forming)" RELATED[ EC:6 ]
    "acetic thiokinase activity" RELATED[ EC:6 ]
    "acetyl activating enzyme" RELATED[ EC:6 ]
    "acetyl CoA ligase activity" RELATED[ EC:6 ]
    "acetyl CoA synthase activity" RELATED[ EC:6 ]
    "acetyl coenzyme A synthetase activity" RELATED[ EC:6 ]
    "acetyl-activating enzyme activity" RELATED[ EC:6 ]
    "acetyl-CoA synthase activity" RELATED[ EC:6 ]
    "acetyl-coenzyme A synthase activity" RELATED[ EC:6 ]
    "acetyl-coenzyme A synthetase activity" EXACT
    "ACS" RELATED[ EC:6 ]
    "acyl-activating enzyme activity" BROAD[ EC:6 ]
    "short chain fatty acyl-CoA synthetase activity" RELATED[ EC:6 ]
    "short-chain acyl-coenzyme A synthetase activity" RELATED[ EC:6 ]
Secondary IDs
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EC:6.2.1.1
MetaCyc:ACETATE--COA-LIGASE-RXN
Reactome:R-HSA-449911 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]"
Reactome:R-HSA-71735 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]"
Reactome:R-HSA-8875071 "ACSS3 ligates CoA to CH3COO-"
RHEA:23176