FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term acetyl-CoA C-acyltransferase activity ID (Ontology) GO:0003988 (Gene Ontology)
Definition Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
Also Known As"2-keto-acyl thiolase activity" ; "3-ketoacyl coenzyme A thiolase activity" ; "3-ketoacyl-CoA thiolase activity" (for all, see Synonyms field below)
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 acetyl-CoA C-acyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | acetyl-CoA C-acyltransferase activity       --
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  acyltransferase activity
   |__acyltransferase activity, transferring groups other than amino-acyl groups
       |__acetyl-CoA C-acyltransferase activity  7 rec.
           |__3-oxoadipyl-CoA thiolase activity
           |__acetyl-CoA C-acetyltransferase activity 4 rec.
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Is a acyltransferase activity, transferring groups other than amino-acyl groups
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Synonyms
  • "2-keto-acyl thiolase activity" EXACT
    "3-ketoacyl coenzyme A thiolase activity" EXACT
    "3-ketoacyl-CoA thiolase activity" EXACT
    "3-ketothiolase activity" EXACT
    "acetoacetyl-CoA beta-ketothiolase activity" EXACT
    "acetyl-CoA acyltransferase activity" EXACT
    "beta-ketoacyl coenzyme A thiolase activity" EXACT
    "beta-ketothiolase activity" EXACT[ EC:2 ]
Secondary IDs
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EC:2.3.1.16
MetaCyc:KETOACYLCOATHIOL-RXN
Reactome:R-HSA-390250 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA"
Reactome:R-HSA-77271 "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA"
Reactome:R-HSA-77304 "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA"
Reactome:R-HSA-77309 "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA"
Reactome:R-HSA-77321 "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA"
Reactome:R-HSA-77329 "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA"
Reactome:R-HSA-77340 "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA"
Reactome:R-HSA-8874745 "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH"
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UM-BBD_reactionID:r1051