FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term aconitate hydratase activity ID (Ontology) GO:0003994 (Gene Ontology)
Definition Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.[ EC:4 ]
Also Known As "aconitase activity"
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       4
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 Gene Groups Genes
 aconitate hydratase activity (all annotations which use CV term, excluding "NOT" statements)       1      4
     enables | aconitate hydratase activity       --       4
Spanning Tree (Parents/Children)
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  carbon-oxygen lyase activity
   |__hydro-lyase activity
       |__aconitate hydratase activity  5 rec.
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Is a hydro-lyase activity
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Synonyms
  • "aconitase activity" EXACT
    "cis-aconitase activity" RELATED[ EC:4 ]
    "citrate hydro-lyase activity" BROAD[ EC:4 ]
    "citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" RELATED[ EC:4 ]
    "citrate(isocitrate) hydro-lyase activity" RELATED[ EC:4 ]
Secondary IDs
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EC:4.2.1.3
MetaCyc:RXN-14047
Reactome:R-HSA-5690911 "ACO1:4Fe-4S isomerises CIT to ISCIT"
Reactome:R-HSA-70971 "ACO2 isomerizes citrate"
RHEA:10336