FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term acyl-CoA dehydrogenase activity ID (Ontology) GO:0003995 (Gene Ontology)
Definition Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].
Also Known As"acyl CoA dehydrogenase activity" ; "acyl coenzyme A dehydrogenase activity" ; "acyl-CoA reductase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 acyl-CoA dehydrogenase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | acyl-CoA dehydrogenase activity       --
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  oxidoreductase activity, acting on the CH-CH group of donors
   |__oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor
       |__acyl-CoA dehydrogenase activity  9 rec.
           |__glutaryl-CoA dehydrogenase activity 1 rec.
           |__long-chain fatty acyl-CoA dehydrogenase activity 2 rec.
           |__medium-chain fatty acyl-CoA dehydrogenase activity 2 rec.
           |__short-chain fatty acyl-CoA dehydrogenase activity 4 rec.
           |   |__3-methylbutanoyl-CoA dehydrogenase activity 1 rec.
           |   |__short-chain 2-methyl fatty acyl-CoA dehydrogenase activity 1 rec.
           |__very-long-chain fatty acyl-CoA dehydrogenase activity 2 rec.
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Is a oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor
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Synonyms
  • "acyl CoA dehydrogenase activity" EXACT
    "acyl coenzyme A dehydrogenase activity" EXACT
    "acyl-CoA reductase activity" EXACT
    "fatty acyl coenzyme A dehydrogenase activity" RELATED
    "fatty-acyl-CoA dehydrogenase activity" RELATED
    "general acyl CoA dehydrogenase activity" RELATED
Secondary IDs
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MetaCyc:ACYLCOADEHYDROG-RXN
Reactome:R-HSA-109341 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA"
Reactome:R-HSA-5695980 "ACAD10 dehydrogenates S-2MPDA-CoA"
Reactome:R-HSA-5695989 "ACAD11 dehydrogenates BH-CoA"
Reactome:R-HSA-70800 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2"
Reactome:R-HSA-70859 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2"
Reactome:R-HSA-77263 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2"
Reactome:R-HSA-77274 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2"
Reactome:R-HSA-77299 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2"
Reactome:R-HSA-77319 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2"
Reactome:R-HSA-77327 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2"
Reactome:R-HSA-77338 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2"
Reactome:R-HSA-77345 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2"
RHEA:44704