FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term acyl-CoA oxidase activity ID (Ontology) GO:0003997 (Gene Ontology)
Definition Catalysis of the reaction: a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2.
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 acyl-CoA oxidase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | acyl-CoA oxidase activity       --
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  oxidoreductase activity, acting on the CH-CH group of donors
   |__oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
       |__acyl-CoA oxidase activity  7 rec.
           |__long-chain fatty acyl-CoA oxidase activity
           |__medium-chain fatty acyl-CoA oxidase activity
           |__pristanoyl-CoA oxidase activity 2 rec.
           |__short-chain fatty acyl-CoA oxidase activity
           |__very-long-chain fatty acyl-CoA oxidase activity
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Is a oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
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Synonyms
  • "acyl coenzyme A oxidase activity" RELATED[ EC:1 ]
    "acyl-CoA:oxygen 2-oxidoreductase activity" RELATED[ EC:1 ]
    "fatty acyl-CoA oxidase activity" RELATED[ EC:1 ]
    "fatty acyl-coenzyme A oxidase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.3.3.6
MetaCyc:RXN-11026
Reactome:R-HSA-192335 "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)"
Reactome:R-HSA-193369 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA"
Reactome:R-HSA-2066787 "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA"
Reactome:R-HSA-390256 "ACOX1 oxidizes C26:0 CoA"
RHEA:22952
RHEA:38959
RHEA:39071
RHEA:39087
RHEA:40271
RHEA:40275
RHEA:40315
RHEA:40471
RHEA:66208
RHEA:66212
RHEA:66216
RHEA:66220
RHEA:66224
RHEA:66228
RHEA:66232
RHEA:66236
RHEA:67212
RHEA:86619
RHEA:86699