FB2026_03 , released September 17, 2026
CV Term Report
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Term aldehyde dehydrogenase (NAD+) activity ID (Ontology) GO:0004029 (Gene Ontology)
Definition Catalysis of the reaction: an aldehyde + H2O + NAD+ = a carboxylate + 2 H+ + NADH.
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 aldehyde dehydrogenase (NAD+) activity (all annotations which use CV term, excluding "NOT" statements)
     enables | aldehyde dehydrogenase (NAD+) activity       --
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  oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
   |__aldehyde dehydrogenase [NAD(P)+] activity
       |__aldehyde dehydrogenase (NAD+) activity  11 rec.
           |__(R)-dehydropantoate dehydrogenase activity
           |__2,5-dioxovalerate dehydrogenase (NAD+) activity
           |__2-formylbenzoate dehydrogenase (NAD+) activity
           |__2-oxoaldehyde dehydrogenase (NAD+) activity
           |__3-aminopropanal dehydrogenase (NAD+) activity
           |__3-deoxyglucosone dehydrogenase (NAD+) activity
           |__4-hydroxybenzaldehyde dehydrogenase (NAD+) activity
           |__4-hydroxymuconic-semialdehyde dehydrogenase (NAD+) activity
           |__4-hydroxyphenylacetaldehyde dehydrogenase (NAD+) activity
           |__4-trimethylammoniobutyraldehyde dehydrogenase (NAD+) activity
           |__5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase (NAD+) activity
           |__abieta-7,13-dien-18-al (NAD+) dehydrogenase activity
           |__acetaldehyde dehydrogenase (NAD+) activity
           |__aminobutyraldehyde dehydrogenase (NAD+) activity
           |__aminomuconate-semialdehyde dehydrogenase (NAD+) activity
           |__aryl-aldehyde dehydrogenase (NAD+) activity
           |__benzaldehyde dehydrogenase (NAD+) activity
           |__betaine-aldehyde dehydrogenase (NAD+) activity 1 rec.
           |__farnesal dehydrogenase (NAD+) activity
           |__fatty aldehyde dehydrogenase (NAD+) activity
           |   |__long-chain fatty aldehyde dehydrogenase (NAD+) activity(+)
           |   |__medium-chain fatty aldehyde dehydrogenase (NAD+) activity
           |__fluoroacetaldehyde dehydrogenase (NAD+) activity
           |__formaldehyde dehydrogenase (NAD+) activity
           |__gamma-guanidinobutyraldehyde dehydrogenase (NAD+) activity
           |__geranial dehydrogenase (NAD+) activity
           |__glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
           |__glycolaldehyde dehydrogenase (NAD+) activity
           |__L-glutamate gamma-semialdehyde dehydrogenase (NAD+) activity 3 rec.
           |__lactaldehyde dehydrogenase (NAD+) activity
           |__phenylacetaldehyde dehydrogenase (NAD+) activity
           |__retinal dehydrogenase (NAD+) activity 1 rec.
           |__salicylaldehyde dehydrogenase (NAD+) activity
           |__succinate-semialdehyde dehydrogenase (NAD+) activity 1 rec.
           |__succinylglutamate-semialdehyde dehydrogenase (NAD+) activity
           |__sulfoacetaldehyde dehydrogenase (NAD+) activity
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Is a aldehyde dehydrogenase [NAD(P)+] activity
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Synonyms
  • "aldehyde dehydrogenase (NAD+)" RELATED[ EC:1 ]
    "aldehyde:NAD+ oxidoreductase activity" RELATED[ EC:1 ]
    "CoA-independent aldehyde dehydrogenase activity" RELATED[ EC:1 ]
    "m-methylbenzaldehyde dehydrogenase activity" RELATED[ EC:1 ]
    "NAD-aldehyde dehydrogenase activity" RELATED[ EC:1 ]
    "NAD-dependent 4-hydroxynonenal dehydrogenase activity" RELATED[ EC:1 ]
    "NAD-dependent aldehyde dehydrogenase activity" RELATED[ EC:1 ]
    "NAD-linked aldehyde dehydrogenase activity" RELATED[ EC:1 ]
    "propionaldehyde dehydrogenase activity" RELATED[ EC:1 ]
Secondary IDs
hide External Crossreferences & Linkouts
EC:1.2.1.3
MetaCyc:ALDHDEHYDROG-RXN
Reactome:R-HSA-380608 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid"
Reactome:R-HSA-389609 "ALDH3A2-2 oxidizes pristanal to pristanate"
Reactome:R-HSA-5692261 "ALDH3A2-1 oxidises HD2NAL to PALM"
Reactome:R-HSA-5696091 "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH"
Reactome:R-HSA-6808487 "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG"
Reactome:R-HSA-6808496 "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG"
Reactome:R-HSA-6813749 "ALDH1A1 oxidises GA to DGA"
Reactome:R-HSA-71691 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]"
Reactome:R-HSA-71723 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]"
RHEA:16185
RHEA:30867
RHEA:30879
RHEA:31043
RHEA:31059
RHEA:31215
RHEA:31231
RHEA:31243
RHEA:31259
RHEA:31299
RHEA:31515
RHEA:33803
RHEA:34219
RHEA:39039
RHEA:42340
RHEA:42384
RHEA:45764
RHEA:47932
RHEA:59432
RHEA:60688
RHEA:60708
RHEA:61632
RHEA:67252
RHEA:67256
RHEA:69080
RHEA:69084
RHEA:69088
RHEA:69164
RHEA:69168
RHEA:75119
RHEA:76655
RHEA:76667
RHEA:81191
RHEA:81419
UM-BBD_reactionID:r0003
UM-BBD_reactionID:r0023
UM-BBD_reactionID:r0605
Wikipedia:Aldehyde_dehydrogenase_(NAD+)