FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term aminoacylase activity ID (Ontology) GO:0004046 (Gene Ontology)
Definition Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid.[ EC:3 ]
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       6
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 aminoacylase activity (all annotations which use CV term, excluding "NOT" statements)       1      6
     enables | aminoacylase activity       --       6
Spanning Tree (Parents/Children)
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  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
   |__hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
       |__aminoacylase activity  7 rec.
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Is a hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Part of
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Synonyms
  • "acylase I activity" NARROW[ EC:3 ]
    "alpha-N-acylaminoacid hydrolase activity" RELATED[ EC:3 ]
    "amido acid deacylase activity" RELATED[ EC:3 ]
    "aminoacylase I activity" NARROW[ EC:3 ]
    "benzamidase activity" RELATED[ EC:3 ]
    "dehydropeptidase II activity" NARROW[ EC:3 ]
    "hippurase activity" RELATED[ EC:3 ]
    "histozyme activity" RELATED[ EC:3 ]
    "L-amino-acid acylase activity" RELATED[ EC:3 ]
    "L-aminoacylase activity" RELATED[ EC:3 ]
    "long acyl amidoacylase activity" RELATED[ EC:3 ]
    "N-acyl-L-amino-acid amidohydrolase activity" RELATED[ EC:3 ]
    "short acyl amidoacylase activity" RELATED[ EC:3 ]
Secondary IDs
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EC:3.5.1.14
MetaCyc:AMINOACYLASE-RXN
Reactome:R-HSA-5433074 "ACY1:Zn2+ dimer hydrolyses mercapturic acids"
Reactome:R-HSA-5579081 "Defective ACY1 does not hydrolyse mercapturic acids"
Reactome:R-HSA-9638046 "ACY3:Zn2+ dimer hydrolyses mercapturic acids"
Reactome:R-HSA-9753944 "ACY1:Zn2+ dimer deacetylates NAC to L-Cys"
RHEA:15565
RHEA:36855
RHEA:47124
RHEA:49796
RHEA:51300
RHEA:51312
RHEA:51316
RHEA:51352
RHEA:51356
RHEA:51360
RHEA:51444
RHEA:51456
RHEA:51460
RHEA:52628
RHEA:54184
RHEA:54188
RHEA:64108
RHEA:64112
RHEA:64116
RHEA:64120
RHEA:64124
RHEA:64128
RHEA:64132
RHEA:64136
RHEA:64140
RHEA:64144
RHEA:64156
RHEA:64176
RHEA:64180
RHEA:64184
RHEA:64188
RHEA:64192
RHEA:64196
RHEA:64200
RHEA:64208
RHEA:64212
RHEA:67368
RHEA:67440
RHEA:75515
RHEA:81115
RHEA:81119
RHEA:81123