FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term argininosuccinate synthase activity ID (Ontology) GO:0004055 (Gene Ontology)
Definition Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate.[ EC:6 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 argininosuccinate synthase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | argininosuccinate synthase activity
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  ligase activity
   |__ligase activity, forming carbon-nitrogen bonds
       |__argininosuccinate synthase activity  1 rec.
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Is a ligase activity, forming carbon-nitrogen bonds
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Synonyms
  • "arginine succinate synthetase activity" RELATED[ EC:6 ]
    "argininosuccinate synthetase activity" RELATED[ EC:6 ]
    "argininosuccinic acid synthetase activity" RELATED[ EC:6 ]
    "arginosuccinate synthetase activity" RELATED[ EC:6 ]
    "citrulline--aspartate ligase activity" RELATED[ EC:6 ]
    "L-citrulline:L-aspartate ligase (AMP-forming)" RELATED[ EC:6 ]
Secondary IDs
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EC:6.3.4.5
MetaCyc:ARGSUCCINSYN-RXN
Reactome:R-HSA-70577 "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA"
Reactome:R-HSA-9956517 "ASS1 variants don't synthesize arginosuccinate"
RHEA:10932