FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term asparagine synthase (glutamine-hydrolyzing) activity ID (Ontology) GO:0004066 (Gene Ontology)
Definition Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate.[ EC:6 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 asparagine synthase (glutamine-hydrolyzing) activity (all annotations which use CV term, excluding "NOT" statements)
     enables | asparagine synthase (glutamine-hydrolyzing) activity
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  ligase activity, forming carbon-nitrogen bonds
   |__carbon-nitrogen ligase activity, with glutamine as amido-N-donor
       |__asparagine synthase (glutamine-hydrolyzing) activity  1 rec.
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Is a carbon-nitrogen ligase activity, with glutamine as amido-N-donor
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Synonyms
  • "AS" RELATED[ EC:6 ]
    "AS-B activity" RELATED[ EC:6 ]
    "asparagine synthase (glutamine-hydrolysing)" RELATED[ EC:6 ]
    "asparagine synthetase (glutamine-hydrolysing)" RELATED[ EC:6 ]
    "asparagine synthetase (glutamine-hydrolyzing) activity" RELATED[ EC:6 ]
    "asparagine synthetase B activity" RELATED[ EC:6 ]
    "glutamine-dependent asparagine synthetase activity" RELATED[ EC:6 ]
    "L-aspartate:L-glutamine amido-ligase (AMP-forming)" RELATED[ EC:6 ]
Secondary IDs
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EC:6.3.5.4
MetaCyc:ASNSYNB-RXN
Reactome:R-HSA-70599 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]"
RHEA:12228