FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term biotin--[biotin carboxyl-carrier protein] ligase activity ID (Ontology) GO:0004077 (Gene Ontology)
Definition Catalysis of the reaction: ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H+ + N(6)-biotinyl-L-lysyl-[protein].
Also Known As"biotin-protein ligase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 biotin--[biotin carboxyl-carrier protein] ligase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | biotin--[biotin carboxyl-carrier protein] ligase activity
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catalytic activity
 |__catalytic activity, acting on a protein_________
ligase activity                                     |
 |__ligase activity, forming carbon-nitrogen bonds__|
                                                    biotin--[biotin carboxyl-carrier protein] ligase activity  1 rec.
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Is a ligase activity, forming carbon-nitrogen bonds
catalytic activity, acting on a protein
Part of
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Synonyms
  • "acetyl CoA holocarboxylase synthetase activity" RELATED[ EC:6 ]
    "acetyl coenzyme A holocarboxylase synthetase activity" RELATED[ EC:6 ]
    "acetyl-CoA carboxylase biotin holoenzyme synthetase activity" RELATED[ EC:6 ]
    "biotin holoenzyme synthetase activity" RELATED[ EC:6 ]
    "biotin--[acetyl-CoA carboxylase] synthetase activity" RELATED[ EC:6 ]
    "biotin--protein ligase activity" RELATED[ EC:6 ]
    "biotin-acetyl coenzyme A carboxylase synthetase activity" RELATED[ EC:6 ]
    "biotin-acetyl-CoA carboxylase synthetase" BROAD[ EC:6 ]
    "biotin-acetyl-CoA-carboxylase ligase activity" RELATED[ EC:6 ]
    "biotin-protein ligase activity" EXACT
    "biotin:apo-acetyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" RELATED[ EC:6 ]
    "biotin:apocarboxylase ligase activity" RELATED[ EC:6 ]
    "HCS" RELATED[ EC:6 ]
Secondary IDs
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EC:6.3.4.10
EC:6.3.4.11
EC:6.3.4.15
EC:6.3.4.9
MetaCyc:6.3.4.10-RXN
MetaCyc:6.3.4.11-RXN
MetaCyc:6.3.4.9-RXN
MetaCyc:BIOTINLIG-RXN
Reactome:R-HSA-2993447 "HLCS biotinylates 6x(PCCA:PCCB)"
Reactome:R-HSA-2993799 "HLCS biotinylates 6xMCCC1:6xMCCC2"
Reactome:R-HSA-2993802 "HLCS biotinylates PC:Mn2+"
Reactome:R-HSA-2993814 "HLCS biotinylates ACACA:Mn2+"
Reactome:R-HSA-3323184 "Defective HLCS does not biotinylate ACACA:Mn2+"
Reactome:R-HSA-4167511 "HLCS biotinylates ACACB"
Reactome:R-HSA-9035987 "Defective HLCS does not biotinylate 6xMCCC1:6xMCCC2"
Reactome:R-HSA-9035988 "Defective HLCS does not biotinylate PC:Mn2+"
Reactome:R-HSA-9035990 "Defective HLCS does not biotinylate 6x(PCCA:PCCB)"
RHEA:11204
RHEA:11756
RHEA:23668
RHEA:24376