FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity ID (Ontology) GO:0004088 (Gene Ontology)
Definition Catalysis of the reaction: hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H+.
Also Known As"carbamoyl phosphate synthase (glutamine-hydrolyzing) activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity (all annotations which use CV term, excluding "NOT" statements)
     enables | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
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  ligase activity, forming carbon-nitrogen bonds
   |__carbon-nitrogen ligase activity, with glutamine as amido-N-donor
       |__carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity  1 rec.
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Is a carbon-nitrogen ligase activity, with glutamine as amido-N-donor
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Synonyms
  • "carbamoyl phosphate synthase (glutamine-hydrolyzing) activity" EXACT
    "carbamoyl phosphate synthetase activity" RELATED[ EC:6 ]
    "carbamoyl-phosphate synthase (glutamine-hydrolysing) activity" RELATED[ EC:6 ]
    "carbamoyl-phosphate synthetase (glutamine-hydrolysing) activity" RELATED[ EC:6 ]
    "carbamoyl-phosphate synthetase (glutamine-hydrolyzing) activity" RELATED[ EC:6 ]
    "carbamoylphosphate synthetase II activity" RELATED[ EC:6 ]
    "carbamyl phosphate synthetase (glutamine) activity" RELATED[ EC:6 ]
    "carbon-dioxide::L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity" RELATED[ EC:6 ]
    "CPS activity" RELATED[ EC:6 ]
    "GD-CPSase activity" RELATED[ EC:6 ]
    "glutamine-dependent carbamoyl-phosphate synthase activity" RELATED[ EC:6 ]
    "glutamine-dependent carbamyl phosphate synthetase activity" RELATED[ EC:6 ]
    "hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity" RELATED[ EC:6 ]
Secondary IDs
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EC:6.3.5.5
MetaCyc:CARBPSYN-RXN
Reactome:R-HSA-73577 "CAD hexamer transforms L-Gln to CAP"
RHEA:18633