FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity ID (Ontology) GO:0004117 (Gene Ontology)
Definition Catalysis of the reactions: 3',5'-cyclic AMP + H2O = AMP + H+ and 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin.[ PubMed:8557689 PubMed:9419816 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
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3',5'-cyclic-nucleotide phosphodiesterase activity
 |__3',5'-cyclic-AMP phosphodiesterase activity__
 |__3',5'-cyclic-GMP phosphodiesterase activity__|
                                                 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity  1 rec.
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Is a 3',5'-cyclic-AMP phosphodiesterase activity
3',5'-cyclic-GMP phosphodiesterase activity
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Synonyms
  • "calmodulin-activated cyclic-nucleotide dual specificity phosphodiesterase activity" RELATED
    "calmodulin-dependent cyclic-nucleotide phosphodiesterase activity" BROAD
Secondary IDs
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Reactome:R-HSA-111955 "cAMP hydrolysis by Cam-PDE 1"