FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term dihydrofolate reductase activity ID (Ontology) GO:0004146 (Gene Ontology)
Definition Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.[ EC:1 ]
Also Known As "dihydrofolate reduction"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 dihydrofolate reductase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | dihydrofolate reductase activity
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Vocabulary search: maintenance 
  oxidoreductase activity, acting on the CH-NH group of donors
   |__oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
       |__dihydrofolate reductase activity  1 rec.
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Is a oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
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Synonyms
  • "5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity" RELATED[ EC:1 ]
    "7,8-dihydrofolate reductase activity" RELATED[ EC:1 ]
    "DHFR" RELATED[ EC:1 ]
    "dihydrofolate reductase:thymidylate synthase activity" RELATED[ EC:1 ]
    "dihydrofolate reduction" EXACT
    "dihydrofolic acid reductase activity" RELATED[ EC:1 ]
    "dihydrofolic reductase activity" RELATED[ EC:1 ]
    "folic acid reductase activity" RELATED[ EC:1 ]
    "folic reductase activity" RELATED[ EC:1 ]
    "NADPH-dihydrofolate reductase activity" RELATED[ EC:1 ]
    "pteridine reductase:dihydrofolate reductase activity" RELATED[ EC:1 ]
    "tetrahydrofolate dehydrogenase activity" RELATED[ EC:1 ]
    "thymidylate synthetase-dihydrofolate reductase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.5.1.3
MetaCyc:DIHYDROFOLATEREDUCT-RXN
Reactome:R-HSA-1497794 "Salvage - BH2 is reduced to BH4 by DHFR"
RHEA:15009