FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term dihydrolipoyl dehydrogenase (NADH) activity ID (Ontology) GO:0004148 (Gene Ontology)
Definition Catalysis of the reaction: N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD+ = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H+.
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 dihydrolipoyl dehydrogenase (NADH) activity (all annotations which use CV term, excluding "NOT" statements)
     enables | dihydrolipoyl dehydrogenase (NADH) activity       --
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  oxidoreductase activity, acting on a sulfur group of donors
   |__oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
       |__dihydrolipoyl dehydrogenase (NADH) activity  9 rec.
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Is a oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
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Synonyms
  • "dehydrolipoate dehydrogenase activity" RELATED[ EC:1 ]
    "diaphorase activity" RELATED[ EC:1 ]
    "dihydrolipoamide dehydrogenase activity" RELATED[ EC:1 ]
    "dihydrolipoamide reduction" RELATED[ EC:1 ]
    "dihydrolipoamide:NAD+ oxidoreductase" RELATED[ EC:1 ]
    "dihydrolipoic dehydrogenase activity" RELATED[ EC:1 ]
    "dihydrolipoylprotein reduction" RELATED[ EC:1 ]
    "dihydrothioctic dehydrogenase activity" RELATED[ EC:1 ]
    "E3 component of alpha-ketoacid dehydrogenase complexes activity" RELATED[ EC:1 ]
    "glycine-cleavage system L-protein activity" RELATED[ EC:1 ]
    "L-protein activity" RELATED[ EC:1 ]
    "LDP-Glc activity" NARROW[ EC:1 ]
    "LDP-Val activity" NARROW[ EC:1 ]
    "lipoamide dehydrogenase (NADH) activity" RELATED[ EC:1 ]
    "lipoamide oxidoreductase (NADH) activity" RELATED[ EC:1 ]
    "lipoamide reductase (NADH) activity" RELATED[ EC:1 ]
    "lipoamide reductase activity" RELATED[ EC:1 ]
    "lipoate dehydrogenase activity" RELATED[ EC:1 ]
    "lipoic acid dehydrogenase activity" RELATED[ EC:1 ]
    "lipoyl dehydrogenase activity" RELATED[ EC:1 ]
    "protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase" RELATED[ EC:1 ]
    "protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase" RELATED[ EC:1 ]
Secondary IDs
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EC:1.8.1.4
MetaCyc:1.8.1.4-RXN
Reactome:R-HSA-1222412 "LpdC dimer reactivates DlaT"
Reactome:R-HSA-5694018 "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate"
Reactome:R-HSA-9853499 "DLD dimer dehydrogenates dihydrolipoyl"
Reactome:R-HSA-9858589 "DLD dimer dehydrogenates dihydrolipoyl"
Reactome:R-HSA-9859172 "DLD dimer dehydrogenates dihydrolipoyl"
Reactome:R-HSA-9861616 "DLD dimer dehydrogenates dihydrolipoyl"
Reactome:R-HSA-9907572 "Loss-of-function DLD mutants don't dehydrogenate dihydrolipoyl DBT"
RHEA:15045