FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
Help Close All Open All
General Information
Term dihydrolipoyl dehydrogenase (NADH) activity ID (Ontology) GO:0004148 (Gene Ontology)
Definition Catalysis of the reaction: N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD+ = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H+.
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 dihydrolipoyl dehydrogenase (NADH) activity (all annotations which use CV term, excluding "NOT" statements)       8      1
     enables | dihydrolipoyl dehydrogenase (NADH) activity       --       1
Spanning Tree (Parents/Children)
Only view relationship: 
  oxidoreductase activity, acting on a sulfur group of donors
   |__oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
       |__dihydrolipoyl dehydrogenase (NADH) activity  9 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "dehydrolipoate dehydrogenase activity" RELATED[ EC:1 ]
    "diaphorase activity" RELATED[ EC:1 ]
    "dihydrolipoamide dehydrogenase activity" RELATED[ EC:1 ]
    "dihydrolipoamide reduction" RELATED[ EC:1 ]
    "dihydrolipoamide:NAD+ oxidoreductase" RELATED[ EC:1 ]
    "dihydrolipoic dehydrogenase activity" RELATED[ EC:1 ]
    "dihydrolipoylprotein reduction" RELATED[ EC:1 ]
    "dihydrothioctic dehydrogenase activity" RELATED[ EC:1 ]
    "E3 component of alpha-ketoacid dehydrogenase complexes activity" RELATED[ EC:1 ]
    "glycine-cleavage system L-protein activity" RELATED[ EC:1 ]
    "L-protein activity" RELATED[ EC:1 ]
    "LDP-Glc activity" NARROW[ EC:1 ]
    "LDP-Val activity" NARROW[ EC:1 ]
    "lipoamide dehydrogenase (NADH) activity" RELATED[ EC:1 ]
    "lipoamide oxidoreductase (NADH) activity" RELATED[ EC:1 ]
    "lipoamide reductase (NADH) activity" RELATED[ EC:1 ]
    "lipoamide reductase activity" RELATED[ EC:1 ]
    "lipoate dehydrogenase activity" RELATED[ EC:1 ]
    "lipoic acid dehydrogenase activity" RELATED[ EC:1 ]
    "lipoyl dehydrogenase activity" RELATED[ EC:1 ]
    "protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase" RELATED[ EC:1 ]
    "protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase" RELATED[ EC:1 ]
Secondary IDs
hide External Crossreferences & Linkouts
EC:1.8.1.4
MetaCyc:1.8.1.4-RXN
Reactome:R-HSA-1222412 "LpdC dimer reactivates DlaT"
Reactome:R-HSA-5694018 "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate"
Reactome:R-HSA-9853499 "DLD dimer dehydrogenates dihydrolipoyl"
Reactome:R-HSA-9858589 "DLD dimer dehydrogenates dihydrolipoyl"
Reactome:R-HSA-9859172 "DLD dimer dehydrogenates dihydrolipoyl"
Reactome:R-HSA-9861616 "DLD dimer dehydrogenates dihydrolipoyl"
Reactome:R-HSA-9907572 "Loss-of-function DLD mutants don't dehydrogenate dihydrolipoyl DBT"
RHEA:15045