FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term aminopeptidase activity ID (Ontology) GO:0004177 (Gene Ontology)
Definition Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain.[ EC:3 PubMed:24157837 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 aminopeptidase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | aminopeptidase activity
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  peptidase activity
   |__exopeptidase activity
       |__aminopeptidase activity  39 rec.
           |__alanyl aminopeptidase activity
           |__cysteine-type aminopeptidase activity 5 rec.
           |__glutamyl aminopeptidase activity
           |__initiator methionyl aminopeptidase activity 1 rec.
           |__metalloaminopeptidase activity 31 rec.
           |__serine-type aminopeptidase activity 1 rec.
           |__tripeptide aminopeptidase activity
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Is a exopeptidase activity
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EC:3.4.11.-
EC:3.4.11.1
EC:3.4.11.21
EC:3.4.11.22
EC:3.4.11.5
EC:3.4.11.6
EC:3.4.11.9
https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE
MetaCyc:3.4.11.21-RXN
MetaCyc:3.4.11.5-RXN
MetaCyc:3.4.11.6-RXN
MetaCyc:3.4.11.9-RXN
MetaCyc:RXN0-5052
Reactome:R-HSA-1236954 "Trimming of peptides by IRAP in endocytic vesicles"
Reactome:R-HSA-2534096 "METAP1/2 demethylates GNAT1"
Reactome:R-HSA-983162 "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases"