FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term metallocarboxypeptidase activity ID (Ontology) GO:0004181 (Gene Ontology)
Definition Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 metallocarboxypeptidase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | metallocarboxypeptidase activity       --
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metallopeptidase activity
 |__metalloexopeptidase activity__
exopeptidase activity             |
 |__carboxypeptidase activity_____|
 |__metalloexopeptidase activity__|
                                  metallocarboxypeptidase activity  22 rec.
                                   |__glutathione S-conjugate carboxypeptidase activity
                                   |__murein tripeptide carboxypeptidase activity
                                   |__tubulin-tyrosine carboxypeptidase activity
                                   |__zinc D-Ala-D-Ala carboxypeptidase activity
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Is a carboxypeptidase activity
metalloexopeptidase activity
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EC:3.4.17.-
EC:3.4.17.1
EC:3.4.17.10
EC:3.4.17.16
EC:3.4.17.2
EC:3.4.17.21
EC:3.4.17.22
EC:3.4.17.3
EC:3.4.17.4
EC:3.4.17.6
MetaCyc:3.4.17.17-RXN
MetaCyc:ALANINE-CARBOXYPEPTIDASE-RXN
MetaCyc:CARBOXYPEPTIDASE-A-RXN
MetaCyc:GLY-X-CARBOXYPEPTIDASE-RXN
MetaCyc:LYSINEARGININE-CARBOXYPEPTIDASE-RXN
Reactome:R-HSA-2022378 "ACE2(18-805):Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9))"
Reactome:R-HSA-2022379 "ACE2(18-805):Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(25-31) (Angiotensin-(1-7))"
Reactome:R-HSA-2028294 "Mast Cell Carboxypeptidase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9))"
Reactome:R-HSA-8852809 "CPN, CPB2 cleave C3a, C5a"
Reactome:R-HSA-8866105 "CCPs deglutamylate tubulin"
Reactome:R-HSA-8955712 "SVBP:VASH1,VASH2 hydrolyzes the terminal L-Tyr residue from alphaY-beta tubulin dimer"
Reactome:R-HSA-9023159 "Carboxypeptidase E hydrolyzes Insulin(57-89) to yield C-peptide (Insulin(57-87))"
Reactome:R-HSA-9023163 "Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54)"
Reactome:R-HSA-9944488 "ACE2:Zn2+ cleaves 1-Ala-AGT(25-32) to yield Alamandine (1-Ala-AGT(25-31)"