FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term aspartic-type endopeptidase activity ID (Ontology) GO:0004190 (Gene Ontology)
Definition Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.[ ISBN:0198506732 ]
Also Known As "aspartic endopeptidase activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Gene Groups Genes
 aspartic-type endopeptidase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | aspartic-type endopeptidase activity       --
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peptidase activity
 |__endopeptidase activity____________
 |__aspartic-type peptidase activity__|
                                      aspartic-type endopeptidase activity  29 rec.
                                       |__aspartic endopeptidase activity, intramembrane cleaving 4 rec.
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Is a endopeptidase activity
aspartic-type peptidase activity
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Synonyms
  • "aspartate protease activity" NARROW
    "aspartic endopeptidase activity" EXACT
    "aspartic protease activity" NARROW
    "aspartyl protease activity" NARROW
    "carboxyl protease activity" NARROW
Secondary IDs
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EC:3.4.23.-
EC:3.4.23.1
EC:3.4.23.15
EC:3.4.23.20
EC:3.4.23.25
EC:3.4.23.32
EC:3.4.23.34
EC:3.4.23.35
EC:3.4.23.36
EC:3.4.23.4
EC:3.4.23.43
EC:3.4.23.49
EC:3.4.23.5
MetaCyc:3.4.23.1-RXN
MetaCyc:3.4.23.15-RXN
MetaCyc:3.4.23.20-RXN
MetaCyc:3.4.23.25-RXN
MetaCyc:3.4.23.32-RXN
MetaCyc:3.4.23.34-RXN
MetaCyc:3.4.23.35-RXN
MetaCyc:3.4.23.4-RXN
MetaCyc:3.4.23.43-RXN
MetaCyc:3.4.23.5-RXN
Reactome:R-HSA-157353 "NEXT1 is cleaved to produce NICD1"
Reactome:R-HSA-157640 "NEXT2 is cleaved to produce NICD2"
Reactome:R-HSA-2022403 "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10))"
Reactome:R-HSA-2022412 "Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10))"
Reactome:R-HSA-2065357 "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10))"
Reactome:R-HSA-2220988 "NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants"
Reactome:R-HSA-373705 "Caspase cleavage of DCC"
Reactome:R-HSA-9013361 "NEXT3 is cleaved to produce NICD3"
Reactome:R-HSA-9017817 "Gamma-secretase cleaves YBX1:NOTCH3"
Reactome:R-HSA-9604294 "Gamma-secretase cleaves NOTCH4"