FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

calcium-dependent cysteine-type endopeptidase activity

ID (Ontology)

GO:0004198 (Gene Ontology)

Definition

Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Gene Groups	Genes
calcium-dependent cysteine-type endopeptidase activity (all annotations which use CV term, excluding "NOT" statements)
enables \| calcium-dependent cysteine-type endopeptidase activity	--
NOT \| enables \| calcium-dependent cysteine-type endopeptidase activity	--

Spanning Tree (Parents/Children)

endopeptidase activity____________
cysteine-type peptidase activity__|
                                  cysteine-type endopeptidase activity
                                   |__calcium-dependent cysteine-type endopeptidase activity  4 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	cysteine-type endopeptidase activity
Part of
Synonyms & Secondary IDs
Synonyms
	"calpain activity" NARROW
Secondary IDs

External Crossreferences & Linkouts
	EC:3.4.22.52 EC:3.4.22.53 EC:3.4.22.54 Reactome:R-HSA-8848658 "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins" Reactome:R-HSA-8863012 "Calpain cleaves p35 to p25" Reactome:R-HSA-9855106 "Calpain2 (m-Calpain) cleaves TLN1 (Talin-1)" Reactome:R-HSA-9861485 "Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin)"