FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term calcium-dependent cysteine-type endopeptidase activity ID (Ontology) GO:0004198 (Gene Ontology)
Definition Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
Comment
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Annotations
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       3
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 calcium-dependent cysteine-type endopeptidase activity (all annotations which use CV term, excluding "NOT" statements)       1      3
     enables | calcium-dependent cysteine-type endopeptidase activity       --       3
 NOT | enables | calcium-dependent cysteine-type endopeptidase activity       --       1
Spanning Tree (Parents/Children)
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endopeptidase activity____________
cysteine-type peptidase activity__|
                                  cysteine-type endopeptidase activity
                                   |__calcium-dependent cysteine-type endopeptidase activity  4 rec.
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Is a cysteine-type endopeptidase activity
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Synonyms
  • "calpain activity" NARROW
Secondary IDs
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EC:3.4.22.52
EC:3.4.22.53
EC:3.4.22.54
Reactome:R-HSA-8848658 "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins"
Reactome:R-HSA-8863012 "Calpain cleaves p35 to p25"
Reactome:R-HSA-9855106 "Calpain2 (m-Calpain) cleaves TLN1 (Talin-1)"
Reactome:R-HSA-9861485 "Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin)"