FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term enoyl-CoA hydratase activity ID (Ontology) GO:0004300 (Gene Ontology)
Definition Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O.[ EC:4 ]
Also Known As"3-hydroxy-fatty acyl-CoA dehydratase" ; "3-hydroxyacyl-CoA dehydratase" ; "short-chain enoyl-CoA hydratase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 enoyl-CoA hydratase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | enoyl-CoA hydratase activity       --
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  carbon-oxygen lyase activity
   |__hydro-lyase activity
       |__enoyl-CoA hydratase activity  10 rec.
           |__3-hydroxyacyl-CoA dehydratase activity 4 rec.
           |   |__(2E)-butenoyl-CoA hydratase activity 1 rec.
           |   |__(2E)-enoyl-CoA hydratase activity(+) 3 rec.
           |__3-hydroxypropionyl-CoA dehydratase activity 1 rec.
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Is a hydro-lyase activity
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Synonyms
  • "(3S)-3-hydroxyacyl-CoA hydro-lyase activity" RELATED
    "2-enoyl-CoA hydratase activity" RELATED
    "2-octenoyl coenzyme A hydrase activity" RELATED
    "3-hydroxy-fatty acyl-CoA dehydratase" EXACT
    "3-hydroxyacyl-CoA dehydratase" EXACT
    "acyl coenzyme A hydrase activity" RELATED
    "beta-hydroxyacid dehydrase activity" RELATED
    "beta-hydroxyacyl-CoA dehydrase activity" RELATED
    "enol-CoA hydratase activity" RELATED[ EC:4 ]
    "enoyl hydrase activity" RELATED[ EC:4 ]
    "short-chain enoyl-CoA hydratase activity" EXACT
    "unsaturated acyl-CoA hydratase activity" RELATED[ EC:4 ]
Secondary IDs
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EC:4.2.1.17
Reactome:R-HSA-70830 "tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA"
Reactome:R-HSA-70870 "ECHS1 hydrates methacrylyl-CoA"
Reactome:R-HSA-77256 "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA"
Reactome:R-HSA-77277 "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA"
Reactome:R-HSA-77301 "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA"
Reactome:R-HSA-77314 "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA"
Reactome:R-HSA-77325 "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA"
Reactome:R-HSA-77333 "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA"
Reactome:R-HSA-77344 "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA"
Reactome:R-HSA-9916717 "ECHS1 mutants don't synthesize beta-hydroxyisobutyryl-CoA"
RHEA:20724