FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term epoxide hydrolase activity ID (Ontology) GO:0004301 (Gene Ontology)
Definition Catalysis of the reaction: an epoxide + H2O = an ethanediol.[ EC:3 ]
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       4
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 Full annotation statements 
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 Gene Groups Genes
 epoxide hydrolase activity (all annotations which use CV term, excluding "NOT" statements)       1      4
     enables | epoxide hydrolase activity       --       4
Spanning Tree (Parents/Children)
Only view relationship: 
  hydrolase activity, acting on ether bonds
   |__ether hydrolase activity
       |__epoxide hydrolase activity  5 rec.
           |__cis-stilbene-oxide hydrolase activity
           |__hepoxilin-epoxide hydrolase activity
           |__juvenile hormone epoxide hydrolase activity 3 rec.
           |__limonene-1,2-epoxide hydrolase activity
           |__phenanthrene-epoxide hydrolase activity
               |__phenanthrene-9,10-epoxide hydrolase activity
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Is a ether hydrolase activity
Part of
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Synonyms
  • "arene-oxide hydratase activity" BROAD[ EC:3 ]
    "aryl epoxide hydrase activity" BROAD[ EC:3 ]
    "cytosolic epoxide hydrolase activity" RELATED[ EC:3 ]
    "epoxide hydrase activity" BROAD[ EC:3 ]
    "epoxide hydratase activity" BROAD[ EC:3 ]
    "sEH" RELATED[ EC:3 ]
    "soluble epoxide hydrolase activity" NARROW[ EC:3 ]
    "trans-stilbene oxide hydrolase activity" RELATED[ EC:3 ]
Secondary IDs
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EC:3.3.2.10
MetaCyc:3.3.2.10-RXN
Reactome:R-HSA-2161961 "5,6-EET is hydrolysed to 5,6-DHET by EPHX2"
Reactome:R-HSA-9018862 "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1"
Reactome:R-HSA-9018877 "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1"
Reactome:R-HSA-9020252 "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2"
Reactome:R-HSA-9020253 "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4"
Reactome:R-HSA-9020257 "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1"
Reactome:R-HSA-9020258 "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2"
Reactome:R-HSA-9020270 "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4"
Reactome:R-HSA-9024890 "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1"
Reactome:R-HSA-9024973 "Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1"
Reactome:R-HSA-9024993 "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2"
Reactome:R-HSA-9025998 "Epoxide hydrolase hydrolyses 13,14-epoxy-DPAn-3 to MaR1n-3 DPA or MaR2n-3 DPA"
Reactome:R-HSA-9026000 "Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA"
Reactome:R-HSA-9026008 "Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA"
Reactome:R-HSA-9915968 "8,9-EET is hydrolysed to 8.9-DHET by EPHX2"
Reactome:R-HSA-9915986 "11,12-EET is hydrolysed to 11,12-DHET by EPHX2"
Reactome:R-HSA-9915994 "14,15-EET is hydrolysed to 14,15-DHET by EPHX2"
RHEA:19037