FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term estradiol 17-beta-dehydrogenase [NAD(P)+] activity ID (Ontology) GO:0004303 (Gene Ontology)
Definition Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor.[ EC:1 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 estradiol 17-beta-dehydrogenase [NAD(P)+] activity (all annotations which use CV term, excluding "NOT" statements)
     enables | estradiol 17-beta-dehydrogenase [NAD(P)+] activity
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steroid dehydrogenase activity_________________________________________________________
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor__|
                                                                                       steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
                                                                                        |__estradiol 17-beta-dehydrogenase [NAD(P)+] activity  9 rec.
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Is a steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
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Synonyms
  • "17-beta-estradiol dehydrogenase activity" RELATED[ EC:1 ]
    "17-beta-HSD activity" BROAD[ EC:1 ]
    "17-beta-hydroxysteroid dehydrogenase activity" BROAD[ EC:1 ]
    "17beta,20alpha-hydroxysteroid dehydrogenase activity" RELATED[ EC:1 ]
    "17beta-estradiol dehydrogenase activity" RELATED[ EC:1 ]
    "17beta-HSD" RELATED[ EC:1 ]
    "17beta-hydroxysteroid dehydrogenase activity" RELATED[ EC:1 ]
    "20alpha-hydroxysteroid dehydrogenase" BROAD[ EC:1 ]
    "estradiol 17-beta-dehydrogenase activity" RELATED
    "estradiol 17beta-dehydrogenase activity" RELATED[ EC:1 ]
    "estradiol dehydrogenase activity" RELATED[ EC:1 ]
    "estradiol-17beta:NAD(P)+ 17-oxidoreductase activity" RELATED[ EC:1 ]
    "estrogen 17-oxidoreductase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.1.1.62
MetaCyc:ESTRADIOL-17-BETA-DEHYDROGENASE-RXN
Reactome:R-HSA-5693390 "HSD17B11 dehydrogenates EST17b to E1"
Reactome:R-HSA-5696822 "AKR1B15 reduces EST17b to E1"
Reactome:R-HSA-6810594 "HSD17B14 tetramer oxidises estradiol (EST17b) to estrone (E1)"
Reactome:R-HSA-804969 "HSD17B1 hydrogenates E1 to EST17b"
Reactome:R-HSA-8862137 "HSD17B2 oxidises estradiol (EST17b) to estrone (E1)"
RHEA:24612
RHEA:24616