FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term ferroxidase activity ID (Ontology) GO:0004322 (Gene Ontology)
Definition Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 ferroxidase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | ferroxidase activity       --
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  oxidoreductase activity, acting on metal ions
   |__oxidoreductase activity, acting on metal ions, oxygen as acceptor
       |__ferroxidase activity  7 rec.
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Is a oxidoreductase activity, acting on metal ions, oxygen as acceptor
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Synonyms
  • "caeruloplasmin" NARROW
    "ceruloplasmin" NARROW[ EC:1 ]
    "Fe(II):oxygen oxidoreductase activity" RELATED
    "ferro:O2 oxidoreductase activity" RELATED
    "ferroxidase I" RELATED
    "ferroxidase, iron II:oxygen oxidoreductase activity" RELATED
    "HEPH" NARROW[ EC:1 ]
    "hephaestin" NARROW[ EC:1 ]
    "iron(II): oxygen oxidoreductase activity" RELATED
    "multicopper ferroxidase iron transport mediator activity" NARROW
Secondary IDs
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EC:1.16.3.1
MetaCyc:RXN0-1483
Reactome:R-HSA-1562603 "BfrB stores iron"
Reactome:R-HSA-1562604 "BfrA stores iron"
Reactome:R-HSA-1562626 "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)"
Reactome:R-HSA-5621402 "Defective CP does not oxidise Fe2+ to Fe3+"
Reactome:R-HSA-5691107 "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)"
Reactome:R-HSA-917891 "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+"
Reactome:R-HSA-917933 "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+"
RHEA:11148