FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term protoporphyrin ferrochelatase activity ID (Ontology) GO:0004325 (Gene Ontology)
Definition Catalysis of the reaction: heme B (protoheme) + H+ = Fe(2+) + protoporphyrin IX.
Also Known As "ferro-protoporphyrin chelatase activity" ; "protoheme ferro-lyase (protoporphyrin-forming)" ; "protoheme ferro-lyase activity" (for all, see Synonyms field below)
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
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 Full annotation statements 
Relevant FlyBase reports
 Genes
 protoporphyrin ferrochelatase activity (all annotations which use CV term, excluding "NOT" statements)       1
     enables | protoporphyrin ferrochelatase activity       1
Spanning Tree (Parents/Children)
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  catalytic activity
   |__lyase activity
       |__protoporphyrin ferrochelatase activity  1 rec.
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Is a lyase activity
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Synonyms
  • "ferro-protoporphyrin chelatase activity" EXACT
    "ferrochelatase activity" BROAD
    "heme synthase activity" BROAD
    "heme synthetase activity" BROAD[ EC:4 ]
    "iron chelatase activity" BROAD[ EC:4 ]
    "protoheme ferro-lyase (protoporphyrin-forming)" EXACT
    "protoheme ferro-lyase activity" EXACT[ EC:4 ]
    "protoheme ferrolyase activity" EXACT
Secondary IDs
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EC:4.98.1.1
KEGG_REACTION:R00310
MetaCyc:PROTOHEMEFERROCHELAT-RXN
Reactome:R-HSA-189465 "FECH binds Fe2+ to PRIN9 to form heme"
RHEA:22584