FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term tetrahydrofolylpolyglutamate synthase activity ID (Ontology) GO:0004326 (Gene Ontology)
Definition Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).[ EC:6 ]
Also Known As"folylpolyglutamate synthase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 tetrahydrofolylpolyglutamate synthase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | tetrahydrofolylpolyglutamate synthase activity
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  ligase activity, forming carbon-nitrogen bonds
   |__acid-amino acid ligase activity
       |__tetrahydrofolylpolyglutamate synthase activity  2 rec.
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Is a acid-amino acid ligase activity
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Synonyms
  • "folate polyglutamate synthetase activity" RELATED[ EC:6 ]
    "folylpoly(gamma-glutamate) synthase activity" RELATED[ EC:6 ]
    "folylpoly-gamma-glutamate synthase activity" RELATED[ EC:6 ]
    "folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity" RELATED[ EC:6 ]
    "folylpolyglutamate synthase activity" EXACT
    "folylpolyglutamate synthetase activity" RELATED[ EC:6 ]
    "folylpolyglutamyl synthetase activity" RELATED[ EC:6 ]
    "formyltetrahydropteroyldiglutamate synthetase activity" RELATED[ EC:6 ]
    "FPGS activity" RELATED[ EC:6 ]
    "N(10)-formyltetrahydropteroyldiglutamate synthetase activity" RELATED[ EC:6 ]
    "N10-formyltetrahydropteroyldiglutamate synthetase activity" RELATED[ EC:6 ]
    "tetrahydrofolate synthase activity" RELATED[ EC:6 ]
    "tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity" RELATED[ EC:6 ]
    "tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming)" RELATED[ EC:6 ]
    "tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)" RELATED[ EC:6 ]
Secondary IDs
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EC:6.3.2.17
MetaCyc:FOLYLPOLYGLUTAMATESYNTH-RXN
Reactome:R-HSA-197958 "FPGS-2 transforms THF to THFPG"
Reactome:R-HSA-200681 "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG"
Reactome:R-HSA-200682 "Mitochondrial FPGS-1 transforms THF to THFPG"
RHEA:10580