FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
Help Close All Open All
General Information
Term tetrahydrofolylpolyglutamate synthase activity ID (Ontology) GO:0004326 (Gene Ontology)
Definition Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).[ EC:6 ]
Also Known As "folylpolyglutamate synthase activity"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       2
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 tetrahydrofolylpolyglutamate synthase activity (all annotations which use CV term, excluding "NOT" statements)       2
     enables | tetrahydrofolylpolyglutamate synthase activity       2
Spanning Tree (Parents/Children)
Only view relationship: 
  ligase activity, forming carbon-nitrogen bonds
   |__acid-amino acid ligase activity
       |__tetrahydrofolylpolyglutamate synthase activity  2 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a acid-amino acid ligase activity
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "folate polyglutamate synthetase activity" RELATED[ EC:6 ]
    "folylpoly(gamma-glutamate) synthase activity" RELATED[ EC:6 ]
    "folylpoly-gamma-glutamate synthase activity" RELATED[ EC:6 ]
    "folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity" RELATED[ EC:6 ]
    "folylpolyglutamate synthase activity" EXACT
    "folylpolyglutamate synthetase activity" RELATED[ EC:6 ]
    "folylpolyglutamyl synthetase activity" RELATED[ EC:6 ]
    "formyltetrahydropteroyldiglutamate synthetase activity" RELATED[ EC:6 ]
    "FPGS activity" RELATED[ EC:6 ]
    "N(10)-formyltetrahydropteroyldiglutamate synthetase activity" RELATED[ EC:6 ]
    "N10-formyltetrahydropteroyldiglutamate synthetase activity" RELATED[ EC:6 ]
    "tetrahydrofolate synthase activity" RELATED[ EC:6 ]
    "tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity" RELATED[ EC:6 ]
    "tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming)" RELATED[ EC:6 ]
    "tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)" RELATED[ EC:6 ]
Secondary IDs
hide External Crossreferences & Linkouts
EC:6.3.2.17
MetaCyc:FOLYLPOLYGLUTAMATESYNTH-RXN
Reactome:R-HSA-197958 "FPGS-2 transforms THF to THFPG"
Reactome:R-HSA-200681 "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG"
Reactome:R-HSA-200682 "Mitochondrial FPGS-1 transforms THF to THFPG"
RHEA:10580