FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term glucokinase activity ID (Ontology) GO:0004340 (Gene Ontology)
Definition Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate.[ EC:2 ]
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 glucokinase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | glucokinase activity
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phosphotransferase activity, alcohol group as acceptor__
carbohydrate kinase activity____________________________|
                                                        hexokinase activity
                                                         |__glucokinase activity  3 rec.
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Is a hexokinase activity
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Synonyms
  • "ATP:D-glucose 6-phosphotransferase activity" RELATED[ EC:2 ]
    "glucokinase (phosphorylating)" RELATED[ EC:2 ]
    "glucose kinase activity" RELATED[ EC:2 ]
Secondary IDs
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EC:2.7.1.2
MetaCyc:GLUCOKIN-RXN
Reactome:R-HSA-5621888 "Defective HK1 does not phosphorylate Glc to form G6P"
Reactome:R-HSA-5621918 "Defective GCK does not phosphorylate Glc to form G6P"
Reactome:R-HSA-70420 "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P"
RHEA:17825
RHEA:36495