FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term glucose-6-phosphate dehydrogenase activity ID (Ontology) GO:0004345 (Gene Ontology)
Definition Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+.[ EC:1 ]
Also Known As "6-phosphoglucose dehydrogenase activity" ; "D-glucose 6-phosphate dehydrogenase activity" ; "G6PDH" (for all, see Synonyms field below)
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       2
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 Full annotation statements 
Relevant FlyBase reports
 Genes
 glucose-6-phosphate dehydrogenase activity (all annotations which use CV term, excluding "NOT" statements)       2
     enables | glucose-6-phosphate dehydrogenase activity       2
 NOT | enables | glucose-6-phosphate dehydrogenase activity       1
Spanning Tree (Parents/Children)
Only view relationship: 
  oxidoreductase activity, acting on CH-OH group of donors
   |__oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
       |__glucose-6-phosphate dehydrogenase activity  2 rec.
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Is a oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
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Synonyms
  • "6-phosphoglucose dehydrogenas" RELATED
    "6-phosphoglucose dehydrogenase activity" EXACT
    "D-glucose 6-phosphate dehydrogenase activity" EXACT
    "D-glucose-6-phosphate:NADP+ 1-oxidoreductase activity" RELATED[ EC:1 ]
    "Entner-doudoroff enzyme" RELATED[ EC:1 ]
    "G6PD activity" RELATED[ EC:1 ]
    "G6PDH" EXACT
    "GDH" RELATED
    "glucose 6-phosphate dehydrogenase (NADP) activity" EXACT
    "glucose-6-phosphate 1-dehydrogenase activity" EXACT
    "NADP-dependent glucose 6-phosphate dehydrogenase activity" EXACT
    "NADP-glucose-6-phosphate dehydrogenase activity" EXACT
    "Zwischenferment" RELATED[ EC:1 ]
Secondary IDs
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EC:1.1.1.49
MetaCyc:GLU6PDEHYDROG-RXN
Reactome:R-HSA-70377 "G6PD multimers dehydrogenate G6P"
RHEA:15841