FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term glucosylceramidase activity ID (Ontology) GO:0004348 (Gene Ontology)
Definition Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.[ EC:3 ]
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       3
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 Gene Groups Genes
 glucosylceramidase activity (all annotations which use CV term, excluding "NOT" statements)       1      3
     enables | glucosylceramidase activity       --       3
Spanning Tree (Parents/Children)
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  hydrolase activity, hydrolyzing O-glycosyl compounds
   |__glycosylceramidase activity
       |__glucosylceramidase activity  4 rec.
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Is a glycosylceramidase activity
Part of
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Synonyms
  • "acid beta-glucosidase activity" RELATED[ EC:3 ]
    "beta-D-glucocerebrosidase activity" RELATED[ EC:3 ]
    "beta-glucocerebrosidase activity" RELATED[ EC:3 ]
    "beta-glucosylceramidase activity" RELATED[ EC:3 ]
    "ceramide glucosidase activity" RELATED[ EC:3 ]
    "D-glucosyl-N-acylsphingosine glucohydrolase activity" RELATED[ EC:3 ]
    "GlcCer-beta-glucosidase activity" RELATED[ EC:3 ]
    "glucocerebrosidase activity" RELATED[ EC:3 ]
    "glucosphingosine glucosylhydrolase activity" RELATED[ EC:3 ]
    "glucosylcerebrosidase activity" RELATED[ EC:3 ]
    "glucosylsphingosine beta-D-glucosidase activity" RELATED[ EC:3 ]
    "glucosylsphingosine beta-glucosidase activity" RELATED[ EC:3 ]
    "psychosine hydrolase activity" RELATED[ EC:3 ]
Secondary IDs
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EC:3.2.1.45
MetaCyc:GLUCOSYLCERAMIDASE-RXN
Reactome:R-HSA-1605591 "GBA1:SAPC hydrolyzes GlcCer"
Reactome:R-HSA-1861788 "GBA2 hydrolyzes GlcCer (plasma membrane)"
Reactome:R-HSA-1861789 "GBA3 hydrolyzes GlcCer (cytosol)"
RHEA:13269
RHEA:59284