FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term glutamate-cysteine ligase activity ID (Ontology) GO:0004357 (Gene Ontology)
Definition Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H+ + phosphate.[ EC:6 ]
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
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 Gene Groups Genes
 glutamate-cysteine ligase activity (all annotations which use CV term, excluding "NOT" statements)       1      1
     enables | glutamate-cysteine ligase activity       --       1
Spanning Tree (Parents/Children)
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  ligase activity, forming carbon-nitrogen bonds
   |__acid-amino acid ligase activity
       |__glutamate-cysteine ligase activity  2 rec.
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Is a acid-amino acid ligase activity
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Synonyms
  • "gamma-glutamyl-L-cysteine synthetase activity" RELATED[ EC:6 ]
    "gamma-glutamylcysteine synthetase activity" RELATED[ EC:6 ]
    "gamma-glutamylcysteinyl synthetase activity" RELATED[ EC:6 ]
    "L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity" RELATED[ EC:6 ]
Secondary IDs
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EC:6.3.2.2
KEGG_REACTION:R00894
MetaCyc:GLUTCYSLIG-RXN
Reactome:R-HSA-174367 "GCL ligates L-Glu to L-Cys"
Reactome:R-HSA-5602892 "Defective GCLC does not ligate L-Glu to L-Cys"
RHEA:13285